Immunoinformatic analysis of the SARS-CoV-2 envelope protein as a strategy to assess cross-protection against COVID-19.
Animals
Betacoronavirus
/ classification
COVID-19
Computational Biology
/ methods
Coronavirus Envelope Proteins
Coronavirus Infections
/ immunology
Epitope Mapping
Gene Expression Regulation, Viral
Humans
Models, Molecular
One Health
Pandemics
Phylogeny
Pneumonia, Viral
/ immunology
Protein Conformation
SARS-CoV-2
Sequence Alignment
Sequence Analysis, Protein
Viral Envelope Proteins
/ immunology
COVID-19
Coronavirus
Diagnosis
Immunoinformatics
One-health
SARS-CoV-2
Journal
Microbes and infection
ISSN: 1769-714X
Titre abrégé: Microbes Infect
Pays: France
ID NLM: 100883508
Informations de publication
Date de publication:
Historique:
received:
05
05
2020
accepted:
19
05
2020
pubmed:
25
5
2020
medline:
1
7
2020
entrez:
25
5
2020
Statut:
ppublish
Résumé
Envelope protein of coronaviruses is a structural protein existing in both monomeric and homo-pentameric form. It has been related to a multitude of roles including virus infection, replication, dissemination and immune response stimulation. In the present study, we employed an immunoinformatic approach to investigate the major immunogenic domains of the SARS-CoV-2 envelope protein and map them among the homologue proteins of coronaviruses with tropism for animal species that are closely inter-related with the human beings population all over the world. Also, when not available, we predicted the envelope protein structural folding and mapped SARS-CoV-2 epitopes. Envelope sequences alignment provides evidence of high sequence homology for some of the investigated virus specimens; while the structural mapping of epitopes resulted in the interesting maintenance of the structural folding and epitope sequence localization also in the envelope proteins scoring a lower alignment score. In line with the One-Health approach, our evidences provide a molecular structural rationale for a potential role of taxonomically related coronaviruses in conferring protection from SARS-CoV-2 infection and identifying potential candidates for the development of diagnostic tools and prophylactic-oriented strategies.
Identifiants
pubmed: 32446902
pii: S1286-4579(20)30091-5
doi: 10.1016/j.micinf.2020.05.013
pmc: PMC7241347
pii:
doi:
Substances chimiques
Coronavirus Envelope Proteins
0
Viral Envelope Proteins
0
envelope protein, SARS-CoV-2
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
182-187Informations de copyright
Copyright © 2020 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The Authors declare no conflict of interest.
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