Fluoxetine and Riluzole Mitigates Manganese-Induced Disruption of Glutamate Transporters and Excitotoxicity via Ephrin-A3/GLAST-GLT-1/Glu Signaling Pathway in Striatum of Mice.
Animals
Corpus Striatum
/ drug effects
Ephrin-A3
/ drug effects
Excitatory Amino Acid Antagonists
/ pharmacology
Excitatory Amino Acid Transporter 1
/ drug effects
Excitatory Amino Acid Transporter 2
/ drug effects
Fluoxetine
/ pharmacology
Glutamic Acid
/ drug effects
Manganese
/ toxicity
Mice
Riluzole
/ pharmacology
Selective Serotonin Reuptake Inhibitors
/ pharmacology
Signal Transduction
Ephrin-A3
Excitotoxicity
Fluoxetine
GLAST
GLT-1
Manganese
Journal
Neurotoxicity research
ISSN: 1476-3524
Titre abrégé: Neurotox Res
Pays: United States
ID NLM: 100929017
Informations de publication
Date de publication:
Aug 2020
Aug 2020
Historique:
received:
31
01
2020
accepted:
14
04
2020
revised:
09
04
2020
pubmed:
31
5
2020
medline:
16
6
2021
entrez:
31
5
2020
Statut:
ppublish
Résumé
Manganese (Mn) is an essential element required for many biological processes and systems in the human body. Mn intoxication increases brain glutamate (Glu) levels causing neuronal damage. Recent studies have reported that ephrin-A3 regulates this glutamate transporter. However, none has explored the role of this crucial molecule in Mn-induced excitotoxicity. The present study investigated whether ephrin-A3/GLAST-GLT-1/Glu signaling pathway participates in Mn-induced excitotoxicity using astrocytes and Kunming mice. The mechanisms were explored using fluoxetine (ephrin-A3 inhibitor) and riluzole (a Glu release inhibitor). Firstly, we demonstrated that Mn exposure (500 μM or 50 mg/kg MnCl
Identifiants
pubmed: 32472497
doi: 10.1007/s12640-020-00209-w
pii: 10.1007/s12640-020-00209-w
doi:
Substances chimiques
Ephrin-A3
0
Excitatory Amino Acid Antagonists
0
Excitatory Amino Acid Transporter 1
0
Excitatory Amino Acid Transporter 2
0
Serotonin Uptake Inhibitors
0
Slc1a2 protein, mouse
0
Slc1a3 protein, mouse
0
Fluoxetine
01K63SUP8D
Glutamic Acid
3KX376GY7L
Manganese
42Z2K6ZL8P
Riluzole
7LJ087RS6F
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
508-523Subventions
Organisme : the National Key Research and Development Project of China
ID : 521/2600019004
Organisme : the National Natural Science Foundation of China
ID : 81302406
Organisme : the Basic Research Fund of Young Program of Higher Education of Liaoning Province
ID : QNK201735
Commentaires et corrections
Type : ErratumIn
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