Methotrexate treatment efficacy in sarcoidosis might be related to TNF-α polymorphism: real life preliminary study.
Adult
Female
Heterozygote
Homozygote
Humans
Immunosuppressive Agents
/ therapeutic use
Lung
/ drug effects
Male
Methotrexate
/ therapeutic use
Middle Aged
Pharmacogenomic Variants
Polymorphism, Genetic
Recovery of Function
Sarcoidosis, Pulmonary
/ diagnosis
Time Factors
Treatment Outcome
Tumor Necrosis Factor-alpha
/ genetics
MTX
TNF-α polymorphism
sarcoidosis
treatment
Journal
Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG
ISSN: 2532-179X
Titre abrégé: Sarcoidosis Vasc Diffuse Lung Dis
Pays: Italy
ID NLM: 9610928
Informations de publication
Date de publication:
2019
2019
Historique:
received:
27
03
2019
accepted:
11
07
2019
entrez:
2
6
2020
pubmed:
1
1
2019
medline:
25
8
2020
Statut:
ppublish
Résumé
Methotrexate therapy improves lung function in selected sarcoidosis patients. Variation in TNF gene was associated with response to treatment. Twenty-eight sarcoidosis patients treated with MTX (6-24 months) were genotyped for No correlation between the initial clinical presentation of sarcoidosis and Two types of positive response to MTX therapy (early and late) in chronic respiratory sarcoidosis are associated with polymorphic changes in TNF gene.
Identifiants
pubmed: 32476962
doi: 10.36141/svdld.v36i4.7708
pii: SVDLD-36-261
pmc: PMC7247097
doi:
Substances chimiques
Immunosuppressive Agents
0
TNF protein, human
0
Tumor Necrosis Factor-alpha
0
Methotrexate
YL5FZ2Y5U1
Types de publication
Comparative Study
Journal Article
Langues
eng
Pagination
261-273Informations de copyright
Copyright: © 2019.
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