Alterations in glycolytic/cholesterogenic gene expression in hepatocellular carcinoma.
Carcinoma, Hepatocellular
/ genetics
Cell Proliferation
Cholesterol
/ biosynthesis
Computational Biology
Datasets as Topic
Gene Amplification
Gene Expression Regulation, Neoplastic
Humans
Kaplan-Meier Estimate
Liver
/ pathology
Liver Neoplasms
/ genetics
Prognosis
Proto-Oncogene Proteins c-myc
/ genetics
RNA-Seq
Tumor Suppressor Protein p53
/ genetics
Warburg Effect, Oncologic
Whole Genome Sequencing
cholesterogenic
glycolysis
hepatocellular carcinoma
metabolic classification
molecular mechanism
Journal
Aging
ISSN: 1945-4589
Titre abrégé: Aging (Albany NY)
Pays: United States
ID NLM: 101508617
Informations de publication
Date de publication:
01 06 2020
01 06 2020
Historique:
received:
27
02
2020
accepted:
20
04
2020
pubmed:
2
6
2020
medline:
9
3
2021
entrez:
2
6
2020
Statut:
ppublish
Résumé
Metabolic reprogramming is a hallmark of tumors, including hepatocellular carcinoma (HCC). We used data from The Cancer Genome Atlas and the International Cancer Genome Consortium to assess the alterations in glycolytic and cholesterogenic genes in HCC and to determine their association with clinical features in HCC patients. Based on the gene expression profiles from these databases, we established four subtypes of HCC: cholesterogenic, glycolytic, mixed, and quiescent. The prognosis of the cholesterogenic subgroup was poorer than that of the glycolytic group. Tumors in the glycolytic group were more sensitive to chemotherapy. We also explored the relationships between these metabolic subtypes and previously established HCC subgroups. Glycolytic gene expression correlated strongly with poorer prognostic gene expression in the Hoshida classification of HCC. Whole-genome analyses indicated that aberrant amplification of
Identifiants
pubmed: 32479426
doi: 10.18632/aging.103254
pii: 103254
pmc: PMC7346031
doi:
Substances chimiques
MYC protein, human
0
Proto-Oncogene Proteins c-myc
0
TP53 protein, human
0
Tumor Suppressor Protein p53
0
Cholesterol
97C5T2UQ7J
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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