Functional Role of Dendritic Cell Subsets in Cancer Progression and Clinical Implications.
Animals
Antigens, Neoplasm
/ immunology
Antineoplastic Agents
/ pharmacology
CD8-Positive T-Lymphocytes
/ immunology
Cell Movement
Chemokines
/ immunology
Cytokines
/ immunology
Dendritic Cells
/ immunology
Disease Progression
Homeostasis
Humans
Immunophenotyping
Immunosuppressive Agents
/ pharmacology
Immunotherapy
Mice
Neoplasms
/ immunology
Prognosis
T-Lymphocytes, Cytotoxic
/ immunology
Treatment Outcome
Tumor Microenvironment
cancer
cancer immunotherapy
chemokines
cytokines
dendritic cell subsets
migration
tumor microenvironment
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
30 May 2020
30 May 2020
Historique:
received:
03
05
2020
revised:
28
05
2020
accepted:
29
05
2020
entrez:
4
6
2020
pubmed:
4
6
2020
medline:
1
4
2021
Statut:
epublish
Résumé
Dendritic cells (DCs) constitute a complex network of cell subsets with common functions but also with many divergent aspects. All dendritic cell subsets share the ability to prime T cell response and to undergo a complex trafficking program related to their stage of maturation and function. For these reasons, dendritic cells are implicated in a large variety of both protective and detrimental immune responses, including a crucial role in promoting anti-tumor responses. Although cDC1s are the most potent subset in tumor antigen cross-presentation, they are not sufficient to induce full-strength anti-tumor cytotoxic T cell response and need close interaction and cooperativity with the other dendritic cell subsets, namely cDC2s and pDCs. This review will take into consideration different aspects of DC biology, including the functional role of dendritic cell subsets in both fostering and suppressing tumor growth, the mechanisms underlying their recruitment into the tumor microenvironment, as well as the prognostic value and the potentiality of dendritic cell therapeutic targeting. Understanding the specificity of dendritic cell subsets will allow to gain insights on role of these cells in pathological conditions and to design new selective promising therapeutic approaches.
Identifiants
pubmed: 32486257
pii: ijms21113930
doi: 10.3390/ijms21113930
pmc: PMC7312661
pii:
doi:
Substances chimiques
Antigens, Neoplasm
0
Antineoplastic Agents
0
Chemokines
0
Cytokines
0
Immunosuppressive Agents
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Associazione Italiana per la Ricerca sul Cancro
ID : IG 2017 - ID 20776
Organisme : MIUR-PRIN 2017
ID : 20177J4E75
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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