Molecular architecture of the human 17S U2 snRNP.

Base Sequence Cryoelectron Microscopy DEAD-box RNA Helicases / chemistry HeLa Cells Humans Models, Molecular Phosphoproteins / chemistry Protein Binding Protein Conformation RNA Splicing Factors / chemistry Ribonucleoprotein, U2 Small Nuclear / chemistry Trans-Activators / chemistry

Journal

Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462

Informations de publication

Date de publication:
07 2020
Historique:
received: 21 11 2019
accepted: 19 03 2020
pubmed: 5 6 2020
medline: 11 8 2020
entrez: 5 6 2020
Statut: ppublish

Résumé

The U2 small nuclear ribonucleoprotein (snRNP) has an essential role in the selection of the precursor mRNA branch-site adenosine, the nucleophile for the first step of splicing

Identifiants

DOI: 10.1038/s41586-020-2344-3 PMID: 32494006
pubmed: 32494006
doi: 10.1038/s41586-020-2344-3
pii: 10.1038/s41586-020-2344-3
doi:

Substances chimiques

HTATSF1 protein, human 0
Phosphoproteins 0
RNA Splicing Factors 0
Ribonucleoprotein, U2 Small Nuclear 0
SF3B1 protein, human 0
Trans-Activators 0
DDX46 protein, human EC 3.6.1.-
DEAD-box RNA Helicases EC 3.6.4.13

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

310-313

Références

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Auteurs

Zhenwei Zhang (Z)

Department of Structural Dynamics, MPI for Biophysical Chemistry, Göttingen, Germany.

Cindy L Will (CL)

Cellular Biochemistry, MPI for Biophysical Chemistry, Göttingen, Germany.

Karl Bertram (K)

Department of Structural Dynamics, MPI for Biophysical Chemistry, Göttingen, Germany.

Olexandr Dybkov (O)

Cellular Biochemistry, MPI for Biophysical Chemistry, Göttingen, Germany.

Klaus Hartmuth (K)

Cellular Biochemistry, MPI for Biophysical Chemistry, Göttingen, Germany.

Dmitry E Agafonov (DE)

Cellular Biochemistry, MPI for Biophysical Chemistry, Göttingen, Germany.

Romina Hofele (R)

Bioanalytical Mass Spectrometry, MPI for Biophysical Chemistry, Göttingen, Germany.
AstraZeneca, Gaithersburg, MD, USA.

Henning Urlaub (H)

Bioanalytical Mass Spectrometry, MPI for Biophysical Chemistry, Göttingen, Germany.
Bioanalytics Group, Institute for Clinical Chemistry, University Medical Center Göttingen, Göttingen, Germany.

Berthold Kastner (B)

Cellular Biochemistry, MPI for Biophysical Chemistry, Göttingen, Germany.

Reinhard Lührmann (R)

Cellular Biochemistry, MPI for Biophysical Chemistry, Göttingen, Germany. reinhard.luehrmann@mpi-bpc.mpg.de.

Holger Stark (H)

Department of Structural Dynamics, MPI for Biophysical Chemistry, Göttingen, Germany. hstark1@gwdg.de.

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Classifications MeSH

questionsmedicales.fr › Sciences de l'information › Sources d'information › Services d'information › Documentation › Données de séquences moléculaires › Séquence nucléotidique › Molecular architecture of the human 17S U2 snRNP.
questionsmedicales.fr › Techniques d'investigation › Microscopie électronique › Cryomicroscopie électronique › Molecular architecture of the human 17S U2 snRNP.
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › Phosphotransferases › Nucleotidyltransferases › RNA nucleotidyltransferases › RNA helicases › DEAD-box RNA helicases › Molecular architecture of the human 17S U2 snRNP.
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules HeLa › Molecular architecture of the human 17S U2 snRNP.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Molecular architecture of the human 17S U2 snRNP.
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles moléculaires › Molecular architecture of the human 17S U2 snRNP.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Phosphoprotéines › Molecular architecture of the human 17S U2 snRNP.
questionsmedicales.fr › Métabolisme › Liaison aux protéines › Molecular architecture of the human 17S U2 snRNP.
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Conformation moléculaire › Conformation des protéines › Molecular architecture of the human 17S U2 snRNP.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Nucléoprotéines › Protéines de liaison à l'ARN › Facteurs d'épissage des ARN › Molecular architecture of the human 17S U2 snRNP.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Nucléoprotéines › Protéines de liaison à l'ARN › Facteurs d'épissage des ARN › Petites ribonucléoprotéines nucléaires U2 › Molecular architecture of the human 17S U2 snRNP.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines virales › Protéines virales régulatrices ou accessoires › Transactivateurs › Molecular architecture of the human 17S U2 snRNP.