Spatial Patterns of Gene Expression in Bacterial Genomes.
Bacteria
Gene expression
Genome location
Genomics
Origin of replication
Terminus of replication
Journal
Journal of molecular evolution
ISSN: 1432-1432
Titre abrégé: J Mol Evol
Pays: Germany
ID NLM: 0360051
Informations de publication
Date de publication:
08 2020
08 2020
Historique:
received:
27
11
2019
accepted:
08
05
2020
pubmed:
9
6
2020
medline:
2
9
2021
entrez:
8
6
2020
Statut:
ppublish
Résumé
Gene expression in bacteria is a remarkably controlled and intricate process impacted by many factors. One such factor is the genomic position of a gene within a bacterial genome. Genes located near the origin of replication generally have a higher expression level, increased dosage, and are often more conserved than genes located farther from the origin of replication. The majority of the studies involved with these findings have only noted this phenomenon in a single gene or cluster of genes that was re-located to pre-determined positions within a bacterial genome. In this work, we look at the overall expression levels from eleven bacterial data sets from Escherichia coli, Bacillus subtilis, Streptomyces, and Sinorhizobium meliloti. We have confirmed that gene expression tends to decrease when moving away from the origin of replication in majority of the replicons analysed in this study. This study sheds light on the impact of genomic location on molecular trends such as gene expression and highlights the importance of accounting for spatial trends in bacterial molecular analysis.
Identifiants
pubmed: 32506154
doi: 10.1007/s00239-020-09951-3
pii: 10.1007/s00239-020-09951-3
pmc: PMC7324424
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
510-520Références
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