Journal
Diabetes
ISSN: 1939-327X
Titre abrégé: Diabetes
Pays: United States
ID NLM: 0372763
Informations de publication
Date de publication:
09 2020
09 2020
Historique:
received:
03
03
2020
accepted:
07
06
2020
pubmed:
13
6
2020
medline:
16
1
2021
entrez:
13
6
2020
Statut:
ppublish
Résumé
Weight loss in response to energy restriction is highly variable, and identification of genetic contributors can provide insights into underlying biology. Leveraging 1000 Genomes imputed genotypes, we carried out genome-wide association study (GWAS) analysis in 551 unrelated obese subjects of European ancestry who participated in an intensively supervised weight loss program with replication of promising signals in an independent sample of 1,331 obese subjects who completed the program at a later date. By single nucleotide polymorphism-based and sib-pair analysis, we show that that weight loss is a heritable trait, with estimated heritability (
Identifiants
pubmed: 32527767
pii: db20-0219
doi: 10.2337/db20-0219
doi:
Substances chimiques
SGCG protein, human
0
Sarcoglycans
0
Banques de données
figshare
['10.2337/figshare.12448796']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2017-2026Subventions
Organisme : CIHR
ID : FDN-154308
Pays : Canada
Informations de copyright
© 2020 by the American Diabetes Association.