Probing Trends in Enantioinduction via Substrate Design: Palladium-Catalyzed Decarboxylative Allylic Alkylation of α-Enaminones.
Journal
Organic letters
ISSN: 1523-7052
Titre abrégé: Org Lett
Pays: United States
ID NLM: 100890393
Informations de publication
Date de publication:
02 07 2020
02 07 2020
Historique:
pubmed:
17
6
2020
medline:
7
7
2021
entrez:
17
6
2020
Statut:
ppublish
Résumé
Herein, we report the palladium-catalyzed decarboxylative asymmetric allylic alkylation of α-enaminones. In addition to serving as valuable synthetic building blocks, we exploit the α-enaminone scaffold and its derivatives as probes to highlight structural and electronic factors that govern enantioselectivity in this asymmetric alkylation reaction. Utilizing the (
Identifiants
pubmed: 32543857
doi: 10.1021/acs.orglett.0c01441
pmc: PMC7608880
mid: NIHMS1637399
doi:
Substances chimiques
Alkenes
0
Carboxylic Acids
0
Ketones
0
Palladium
5TWQ1V240M
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
4966-4969Subventions
Organisme : NIGMS NIH HHS
ID : F32 GM116304
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM080269
Pays : United States
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