Determination of RNA structural diversity and its role in HIV-1 RNA splicing.
Algorithms
Alternative Splicing
/ genetics
Base Sequence
Gene Expression Regulation, Viral
HEK293 Cells
HIV-1
/ genetics
Humans
Mutation
Nucleic Acid Conformation
RNA Folding
RNA Splice Sites
/ genetics
RNA, Viral
/ chemistry
Reproducibility of Results
Sequence Analysis, RNA
Sulfuric Acid Esters
Thermodynamics
Journal
Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462
Informations de publication
Date de publication:
06 2020
06 2020
Historique:
received:
12
05
2019
accepted:
04
03
2020
entrez:
20
6
2020
pubmed:
20
6
2020
medline:
22
9
2020
Statut:
ppublish
Résumé
Human immunodeficiency virus 1 (HIV-1) is a retrovirus with a ten-kilobase single-stranded RNA genome. HIV-1 must express all of its gene products from a single primary transcript, which undergoes alternative splicing to produce diverse protein products that include structural proteins and regulatory factors
Identifiants
pubmed: 32555469
doi: 10.1038/s41586-020-2253-5
pii: 10.1038/s41586-020-2253-5
pmc: PMC7310298
mid: NIHMS1572068
doi:
Substances chimiques
RNA Splice Sites
0
RNA, Viral
0
Sulfuric Acid Esters
0
dimethyl sulfate
JW5CW40Z50
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
438-442Subventions
Organisme : NIAID NIH HHS
ID : R01 AI050470
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI134365
Pays : United States
Organisme : NIAID NIH HHS
ID : U54 AI150470
Pays : United States
Commentaires et corrections
Type : ErratumIn
Références
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