Identification of Common Deletions in the Spike Protein of Severe Acute Respiratory Syndrome Coronavirus 2.
Amino Acid Sequence
Animals
Base Sequence
Betacoronavirus
/ genetics
COVID-19
Cell Line
Chlorocebus aethiops
Coronavirus Infections
/ virology
Furin
/ metabolism
Genome, Viral
Host Specificity
Kinetics
Models, Molecular
Pandemics
Pneumonia, Viral
/ virology
Protein Conformation
SARS-CoV-2
Sequence Analysis
Sequence Deletion
Spike Glycoprotein, Coronavirus
/ chemistry
Vero Cells
Virus Replication
COVID-19
SARS-CoV-2
deletion mutation
replication kinetics
spike protein
Journal
Journal of virology
ISSN: 1098-5514
Titre abrégé: J Virol
Pays: United States
ID NLM: 0113724
Informations de publication
Date de publication:
17 08 2020
17 08 2020
Historique:
received:
26
04
2020
accepted:
16
06
2020
pubmed:
24
6
2020
medline:
2
9
2020
entrez:
24
6
2020
Statut:
epublish
Résumé
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel coronavirus first identified in December 2019. Notable features that make SARS-CoV-2 distinct from most other previously identified betacoronaviruses include a receptor binding domain and a unique insertion of 12 nucleotides or 4 amino acids (PRRA) at the S1/S2 boundary. In this study, we identified two deletion variants of SARS-CoV-2 that either directly affect the polybasic cleavage site itself (NSPRRAR) or a flanking sequence (QTQTN). These deletions were verified by multiple sequencing methods.
Identifiants
pubmed: 32571797
pii: JVI.00790-20
doi: 10.1128/JVI.00790-20
pmc: PMC7431800
pii:
doi:
Substances chimiques
Spike Glycoprotein, Coronavirus
0
spike protein, SARS-CoV-2
0
Furin
EC 3.4.21.75
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/J014370/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/M501621/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/S007555/1
Pays : United Kingdom
Informations de copyright
Copyright © 2020 American Society for Microbiology.
Références
J Mol Evol. 1985;22(2):160-74
pubmed: 3934395
Genome Med. 2020 Jul 28;12(1):68
pubmed: 32723359
Science. 2004 Mar 12;303(5664):1666-9
pubmed: 14752165
Nat Med. 2020 Apr;26(4):450-452
pubmed: 32284615
Cell. 2020 Apr 16;181(2):281-292.e6
pubmed: 32155444
Nat Protoc. 2017 Jun;12(6):1261-1276
pubmed: 28538739
Viruses. 2019 Sep 09;11(9):
pubmed: 31505793
Genomics Proteomics Bioinformatics. 2017 Feb;15(1):14-18
pubmed: 28387199
Antiviral Res. 2020 Apr;176:104742
pubmed: 32057769
Nature. 2020 Apr;580(7803):E7
pubmed: 32296181
Nature. 2020 Jul;583(7815):286-289
pubmed: 32380510
Sci Rep. 2018 Oct 11;8(1):15177
pubmed: 30310104
Nature. 2020 Jul;583(7815):282-285
pubmed: 32218527
J Mol Evol. 1994 Sep;39(3):306-14
pubmed: 7932792
Nat Rev Microbiol. 2019 Mar;17(3):181-192
pubmed: 30531947
Science. 2005 Sep 16;309(5742):1864-8
pubmed: 16166518
Curr Biol. 2020 Jun 8;30(11):2196-2203.e3
pubmed: 32416074
Genome Biol. 2019 Jan 8;20(1):8
pubmed: 30621750
Nucleic Acids Res. 2020 Jan 8;48(D1):D24-D33
pubmed: 31702008
Cell. 2020 Apr 16;181(2):271-280.e8
pubmed: 32142651
Bioinformatics. 2018 Sep 15;34(18):3094-3100
pubmed: 29750242
Cell. 2020 May 28;181(5):997-1003.e9
pubmed: 32359424
Syst Biol. 2010 May;59(3):307-21
pubmed: 20525638