Circulating Levels of Brain-Enriched MicroRNAs Correlate with Neuron Specific Enolase after Cardiac Arrest-A Substudy of the Target Temperature Management Trial.
biomarker
cardiac arrest
microRNAs
neurological function
prognostic
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
19 Jun 2020
19 Jun 2020
Historique:
received:
14
05
2020
revised:
15
06
2020
accepted:
17
06
2020
entrez:
25
6
2020
pubmed:
25
6
2020
medline:
13
2
2021
Statut:
epublish
Résumé
Outcome prognostication after cardiac arrest (CA) is challenging. Current multimodal prediction approaches would benefit from new biomarkers. MicroRNAs constitute a novel class of disease markers and circulating levels of brain-enriched ones have been associated with outcome after CA. To determine whether these levels reflect the extent of brain damage in CA patients, we assessed their correlation with neuron-specific enolase (NSE), a marker of brain damage. Blood samples taken 48 h after return of spontaneous circulation from two groups of patients from the Targeted Temperature Management trial were used. Patients were grouped depending on their neurological outcome at six months. Circulating levels of microRNAs were assessed by sequencing. NSE was measured at the same time-point. Among the 673 microRNAs detected, brain-enriched miR9-3p, miR124-3p and miR129-5p positively correlated with NSE levels (all
Identifiants
pubmed: 32575355
pii: ijms21124353
doi: 10.3390/ijms21124353
pmc: PMC7352657
pii:
doi:
Substances chimiques
Biomarkers
0
MIRN124 microRNA, human
0
MIRN92 microRNA, human
0
MicroRNAs
0
Mirn129 microRNA, human
0
Phosphopyruvate Hydratase
EC 4.2.1.11
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : European Cooperation in Science and Technology
ID : Action EU-CardioRNA CA17129
Organisme : Fonds National de la Recherche Luxembourg
ID : C14/BM/8225223
Organisme : Fonds National de la Recherche Luxembourg
ID : C17/BM/11613033
Organisme : the Ministry of Higher Education and Research Luxembourg
ID : na
Organisme : Heart Foundation - Daniel Wagner of Luxembourg
ID : na
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