Optimal Ratio of Carbon Flux between Glycolysis and the Pentose Phosphate Pathway for Amino Acid Accumulation in
Corynebacterium glutamicum
amino acid
glycolysis
metabolic flux
metabolomics
pentose phosphate pathway
Journal
ACS synthetic biology
ISSN: 2161-5063
Titre abrégé: ACS Synth Biol
Pays: United States
ID NLM: 101575075
Informations de publication
Date de publication:
17 07 2020
17 07 2020
Historique:
pubmed:
1
7
2020
medline:
28
5
2021
entrez:
1
7
2020
Statut:
ppublish
Résumé
Glucose is metabolized through central metabolic pathways such as glycolysis and the pentose phosphate pathway (PPP) to synthesize downstream metabolites including amino acids. However, how the split ratio of carbon flux between glycolysis and PPP specifically affects the formation of downstream metabolites remains largely unclear. Here, we conducted a comprehensive metabolomic analysis to investigate the effect of the split ratio between glycolysis and the PPP on the intracellular concentration of amino acids and their derivatives in
Identifiants
pubmed: 32602337
doi: 10.1021/acssynbio.0c00181
doi:
Substances chimiques
Amino Acids
0
Glucose-6-Phosphate Isomerase
EC 5.3.1.9
Leucine
GMW67QNF9C
Alanine
OF5P57N2ZX
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM