Rhodosporidium toruloides - A potential red yeast chassis for lipids and beyond.
Rhodosporidium toruloides
chassis organism
genetic modification
microbial lipids
multi-omic analysis
Journal
FEMS yeast research
ISSN: 1567-1364
Titre abrégé: FEMS Yeast Res
Pays: England
ID NLM: 101085384
Informations de publication
Date de publication:
01 08 2020
01 08 2020
Historique:
received:
10
05
2020
accepted:
12
06
2020
pubmed:
3
7
2020
medline:
25
9
2021
entrez:
3
7
2020
Statut:
ppublish
Résumé
The red yeast Rhodosporidium toruloides naturally produces microbial lipids and carotenoids. In the past decade or so, many studies demonstrated R. toruloides as a promising platform for lipid production owing to its diverse substrate appetites, robust stress resistance and other favorable features. Also, significant progresses have been made in genome sequencing, multi-omic analysis and genome-scale modeling, thus illuminating the molecular basis behind its physiology, metabolism and response to environmental stresses. At the same time, genetic parts and tools are continuously being developed to manipulate this distinctive organism. Engineered R. toruloides strains are emerging for enhanced production of conventional lipids, functional lipids as well as other interesting metabolites. This review updates those progresses and highlights future directions for advanced biotechnological applications.
Identifiants
pubmed: 32614407
pii: 5866477
doi: 10.1093/femsyr/foaa038
pmc: PMC7334043
pii:
doi:
Substances chimiques
Lipids
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© FEMS 2020.
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