Annonaceae Family Alkaloids as Agents Against Leishmaniasis: A Review and Molecular Docking Evaluation.
Annonaceae
Leishmania donovani
N-myristoyltransferase
alkaloids
docking
isoquinoline
leishmaniasis
neglected diseases
Journal
Current drug metabolism
ISSN: 1875-5453
Titre abrégé: Curr Drug Metab
Pays: Netherlands
ID NLM: 100960533
Informations de publication
Date de publication:
2020
2020
Historique:
received:
23
01
2020
revised:
27
04
2020
accepted:
12
05
2020
pubmed:
3
7
2020
medline:
9
10
2021
entrez:
3
7
2020
Statut:
ppublish
Résumé
Leishmaniasis is a neglected disease that affects 15 million people worldwide. Existing treatments are associated with limitations, including high costs and toxicity. Several classes of natural substances have been reported to display leishmanicidal activity in the literature. Isoquinoline alkaloids, which are commonly found in the Annonaceae family, represent an important skeleton for the development of anti-leishmaniasis products. This study presents an overview of the potential use of Annonaceae alkaloids to treat leishmaniasis and describes a molecular docking study examining 215 isoquinoline alkaloids. All selected compounds contain a bisbenzyltetrahydroisoquinoline, suggesting the affinity of this skeleton for the target.
Identifiants
pubmed: 32614742
pii: CDM-EPUB-107847
doi: 10.2174/1389200221666200702124046
doi:
Substances chimiques
Alkaloids
0
Antiprotozoal Agents
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
482-492Informations de copyright
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