What do we know about DNA mechanics so far?

DNA / genetics Mechanical Phenomena Nanotechnology

Journal

Current opinion in structural biology
ISSN: 1879-033X
Titre abrégé: Curr Opin Struct Biol
Pays: England
ID NLM: 9107784

Informations de publication

Date de publication:
10 2020
Historique:
received: 12 03 2020
accepted: 17 05 2020
pubmed: 3 7 2020
medline: 16 10 2021
entrez: 3 7 2020
Statut: ppublish

Résumé

The DNA molecule, apart from carrying the genetic information, plays a crucial role in a variety of biological processes and finds applications in drug design, nanotechnology and nanoelectronics. The molecule undergoes significant structural transitions under the influence of forces due to physiological and non-physiological environments. Here, we summarize the insights gained from simulations and single-molecule experiments on the structural transitions and mechanics of DNA under force, as well as its elastic properties, in various environmental conditions, and discuss appealing future directions.

Identifiants

DOI: 10.1016/j.sbi.2020.05.010 PMID: 32615513
pubmed: 32615513
pii: S0959-440X(20)30080-4
doi: 10.1016/j.sbi.2020.05.010
pii:
doi:

Substances chimiques

DNA 9007-49-2

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

42-50

Informations de copyright

Copyright © 2020 Elsevier Ltd. All rights reserved.

Auteurs

Abhishek Aggarwal (A)

Center for Condensed Matter Theory, Department of Physics, Indian Institute of Science, Bangalore 560012, India.

Supriyo Naskar (S)

Center for Condensed Matter Theory, Department of Physics, Indian Institute of Science, Bangalore 560012, India.

Anil Kumar Sahoo (AK)

Center for Condensed Matter Theory, Department of Physics, Indian Institute of Science, Bangalore 560012, India.

Santosh Mogurampelly (S)

Department of Physics, Indian Institute of Technology Jodhpur, Rajasthan 342037, India.

Ashok Garai (A)

Department of Physics, The LNM Institute of Information Technology, Sumel, Jaipur, Rajasthan 302031, India.

Prabal K Maiti (PK)

Center for Condensed Matter Theory, Department of Physics, Indian Institute of Science, Bangalore 560012, India. Electronic address: maiti@iisc.ac.in.

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Classifications MeSH

questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ADN › What do we know about DNA mechanics so far?
questionsmedicales.fr › Phénomènes physiques › Phénomènes mécaniques › What do we know about DNA mechanics so far?
questionsmedicales.fr › Technologie, industrie et agriculture › Technologie › Miniaturisation › Nanotechnologie › What do we know about DNA mechanics so far?