Late ESCRT machinery mediates the recycling and Rescue of Invariant Surface Glycoprotein 65 in Trypanosoma brucei.
Cell Line
Endocytosis
Endosomal Sorting Complexes Required for Transport
/ metabolism
Endosomes
/ metabolism
Homeostasis
Lysosomes
/ metabolism
Membrane Glycoproteins
/ metabolism
Phosphatidylinositol 4,5-Diphosphate
/ metabolism
Phosphatidylinositol Phosphates
/ metabolism
Protein Transport
Protozoan Proteins
/ genetics
Trypanosoma brucei brucei
/ growth & development
Variant Surface Glycoproteins, Trypanosoma
/ metabolism
Journal
Cellular microbiology
ISSN: 1462-5822
Titre abrégé: Cell Microbiol
Pays: India
ID NLM: 100883691
Informations de publication
Date de publication:
11 2020
11 2020
Historique:
received:
08
06
2020
revised:
25
06
2020
accepted:
26
06
2020
pubmed:
4
7
2020
medline:
31
7
2021
entrez:
4
7
2020
Statut:
ppublish
Résumé
The Endosomal Sorting Complex Required for Transport machinery consists of four protein complexes (ESCRT 0-IV) and the post ESCRT ATPase Vps4. ESCRT mediates cargo delivery for lysosomal degradation via formation of multivesicular bodies. Trypanosoma brucei contains orthologues of ESCRT I-III and Vps4. Trypanosomes also have an ubiquitinylated invariant surface glycoprotein (ISG65) that is delivered to the lysosome by ESCRT, however, we previously implicated TbVps4 in rescue and recycling of ISG65. Here we use conditional silencing to investigate the role of TbVps24, a phosphoinositide-binding ESCRT III component, on protein trafficking. TbVps24 localises to the TbRab7
Identifiants
pubmed: 32618070
doi: 10.1111/cmi.13244
pmc: PMC7768898
mid: NIHMS1608264
doi:
Substances chimiques
Endosomal Sorting Complexes Required for Transport
0
Membrane Glycoproteins
0
Phosphatidylinositol 4,5-Diphosphate
0
Phosphatidylinositol Phosphates
0
Protozoan Proteins
0
Variant Surface Glycoproteins, Trypanosoma
0
phosphatidylinositol 3,5-diphosphate
0
ISG65 protein, Trypanosoma brucei
147338-68-9
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
e13244Subventions
Organisme : NIAID NIH HHS
ID : R01 AI056866
Pays : United States
Informations de copyright
© 2020 John Wiley & Sons Ltd.
Références
Exp Cell Res. 2008 Feb 15;314(4):801-13
pubmed: 18031739
J Biol Chem. 2004 Dec 24;279(52):54887-95
pubmed: 15342636
Mol Biochem Parasitol. 2007 Dec;156(2):175-90
pubmed: 17869353
Mol Biol Cell. 2006 Sep;17(9):3989-4001
pubmed: 16837550
Mol Biochem Parasitol. 1999 Mar 15;99(1):89-101
pubmed: 10215027
Nature. 2005 Dec 1;438(7068):597-604
pubmed: 16319879
J Cell Sci. 2001 Jul;114(Pt 14):2605-15
pubmed: 11683388
Nature. 2006 Oct 12;443(7112):651-7
pubmed: 17035995
EMBO J. 2015 Oct 1;34(19):2398-407
pubmed: 26311197
J Cell Sci. 2002 Aug 15;115(Pt 16):3253-63
pubmed: 12140257
J Biol Chem. 2003 Oct 3;278(40):38786-95
pubmed: 12878588
Mol Biol Cell. 2009 Nov;20(22):4739-50
pubmed: 19759175
Mol Microbiol. 2011 Nov;82(3):664-78
pubmed: 21923766
Traffic. 2009 Jul;10(7):883-93
pubmed: 19582903
J Cell Sci. 2004 Mar 1;117(Pt 7):1105-15
pubmed: 14996937
J Cell Sci. 2014 May 15;127(Pt 10):2351-64
pubmed: 24639465
Traffic. 2008 Sep;9(10):1698-716
pubmed: 18637903
Nat Rev Mol Cell Biol. 2020 Jan;21(1):25-42
pubmed: 31705132
J Biol Chem. 2003 Jul 4;278(27):24665-72
pubmed: 12716904
J Protozool. 1990 Nov-Dec;37(6):546-52
pubmed: 2086784
Eukaryot Cell. 2005 May;4(5):971-80
pubmed: 15879531
Biochem J. 1998 Nov 1;335 ( Pt 3):681-9
pubmed: 9794811
Mol Biochem Parasitol. 2007 Jun;153(2):220-3
pubmed: 17408766
Mol Biol Cell. 2011 Sep;22(17):3192-205
pubmed: 21757541
Eukaryot Cell. 2013 Feb;12(2):330-42
pubmed: 23264644
Mol Microbiol. 2004 Aug;53(3):735-44
pubmed: 15255888
Cell Microbiol. 2019 Apr;21(4):e12980
pubmed: 30427109
Traffic. 2013 Oct;14(10):1078-90
pubmed: 23905922
Trends Parasitol. 2013 May;29(5):207-12
pubmed: 23601931
Biochemistry. 2009 Oct 13;48(40):9321-3
pubmed: 19673488
Mol Biochem Parasitol. 1989 Jan 1;32(1):85-92
pubmed: 2911281
J Biol Chem. 2002 Mar 15;277(11):9529-39
pubmed: 11751913
Eur J Biochem. 2000 Jun;267(11):3309-14
pubmed: 10824117
Physiol Rev. 2013 Jul;93(3):1019-137
pubmed: 23899561
J Cell Sci. 2018 Jul 6;131(13):
pubmed: 29980602
J Proteome Res. 2008 Dec;7(12):5295-313
pubmed: 19367725
Parasitol Today. 1994 Feb;10(2):80-4
pubmed: 15275508
Eukaryot Cell. 2009 Sep;8(9):1352-61
pubmed: 19581441
Mol Biochem Parasitol. 1999 Jan 5;98(1):17-28
pubmed: 10029306
PLoS Pathog. 2015 Oct 22;11(10):e1005236
pubmed: 26492041
J Cell Sci. 2001 Jul;114(Pt 14):2617-26
pubmed: 11683389
Cell. 2016 Jan 14;164(1-2):246-257
pubmed: 26771494
Mol Microbiol. 2008 May;68(4):933-46
pubmed: 18430083
Eukaryot Cell. 2011 Jul;10(7):916-31
pubmed: 21571921
Mol Biol Cell. 2003 May;14(5):2029-40
pubmed: 12802073
Curr Opin Microbiol. 2012 Aug;15(4):463-8
pubmed: 22445359
Nat Rev Mol Cell Biol. 2017 Jan;18(1):5-17
pubmed: 27703243
J Biol Chem. 1992 May 25;267(15):10791-6
pubmed: 1587855
Mol Microbiol. 2011 Dec;82(6):1433-43
pubmed: 22026408
J Cell Sci. 2011 Nov 15;124(Pt 22):3771-83
pubmed: 22100919
Traffic. 2018 Jun;19(6):406-420
pubmed: 29582527
Traffic. 2008 Sep;9(10):1681-97
pubmed: 18657071
Mol Biochem Parasitol. 2017 Jun;214:52-61
pubmed: 28356223