Elevated plasma phenylalanine predicts mortality in critical patients with heart failure.
Biomarkers
Heart failure
Phenylalanine
Prognosis
Journal
ESC heart failure
ISSN: 2055-5822
Titre abrégé: ESC Heart Fail
Pays: England
ID NLM: 101669191
Informations de publication
Date de publication:
10 2020
10 2020
Historique:
received:
17
03
2020
revised:
21
06
2020
accepted:
24
06
2020
pubmed:
4
7
2020
medline:
22
6
2021
entrez:
4
7
2020
Statut:
ppublish
Résumé
Previous studies found a relationship between elevated phenylalanine levels and poor cardiovascular outcomes. Potential strategies are available to manipulate phenylalanine metabolism. This study investigated whether increased phenylalanine predicted mortality in critical patients with either acute heart failure (HF) or acute on chronic HF, and its correlation with inflammation and immune cytokines. This study recruited 152 subjects, including 115 patients with HF admitted for critical conditions and 37 normal controls. We measured left ventricular ejection fraction (LVEF), plasma concentrations of phenylalanine, C-reactive protein, albumin, pre-albumin, transferrin, and pro-inflammatory and immune cytokines. Acute Physiology and Chronic Health Evaluation (APACHE II), Sequential Organ Failure Assessment (SOFA), and maximal vasoactive-inotropic scores (VIS Elevated phenylalanine levels predicted mortality in critical patients, phenotypically predominantly presenting with HF, independently of traditional prognostic factors and cytokines associated with inflammation and immunity.
Identifiants
pubmed: 32618142
doi: 10.1002/ehf2.12896
pmc: PMC7524095
doi:
Substances chimiques
Phenylalanine
47E5O17Y3R
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2884-2893Subventions
Organisme : Chang Gung Memorial Hospital
ID : 2G0631
Pays : International
Organisme : Chang Gung Memorial Hospital
ID : 2G0621
Pays : International
Organisme : Chang Gung Memorial Hospital
ID : 2G0601
Pays : International
Organisme : Chang Gung Memorial Hospital
ID : CMRPG2G0591
Pays : International
Organisme : Ministry of Science and Technology of Taiwan
ID : MOST107-2314-B-182-071-MY2
Pays : International
Informations de copyright
© 2020 The Authors. ESC Heart Failure published by John Wiley & Sons Ltd on behalf of the European Society of Cardiology.
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