Isolation and evaluation of trypanocidal activity of sesquiterpenoids, flavonoids, and lignans in Artemisia sieversiana collected in Mongolia.
Artemisia sieversiana
Compositae
Lignan
Polymethoxyflavonoid
Sesquiterpenoid
Trypanosoma congolense
Journal
Journal of natural medicines
ISSN: 1861-0293
Titre abrégé: J Nat Med
Pays: Japan
ID NLM: 101518405
Informations de publication
Date de publication:
Sep 2020
Sep 2020
Historique:
received:
14
05
2020
accepted:
22
06
2020
pubmed:
6
7
2020
medline:
2
10
2020
entrez:
5
7
2020
Statut:
ppublish
Résumé
Artemisia sieversiana is an annual herbaceous plant distributed throughout Central and East Eurasia and is regarded as an undesirable forage plant in Mongolia. It affects livestock, so information about its chemical composition is needed. We isolated three new sesquiterpenoids (1-3) and known compounds from A. sieversiana and investigated their activities. The absolute configuration of 1 was established using single-crystal X-ray diffraction crystallography, and its configuration differed from those of reported compounds with similar structures. Two additional new sesquiterpenoids (2 and 3) with similar structures were identified, and their configurations were determined. The trypanocidal activities of the isolated compounds (1-18) against Trypanosoma congolense and the pathogen responsible for fatal trypanosomosis in animals were estimated. Flavonoids and lignans were identified as active compounds with IC
Identifiants
pubmed: 32621255
doi: 10.1007/s11418-020-01429-2
pii: 10.1007/s11418-020-01429-2
doi:
Substances chimiques
Flavonoids
0
Lignans
0
Sesquiterpenes
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
750-757Subventions
Organisme : Consulting service project from the Ministry of Food, Agriculture and Light Industry of Mongolia
ID : 190812/04.294
Organisme : JSPS Kakenhi
ID : JP19K16397
Organisme : Cooperative Research Grant from the National Research Center for Protozoan Diseases
ID : 31-joint-5
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