Neuro-oxysterols and neuro-sterols as ligands to nuclear receptors, GPCRs, ligand-gated ion channels and other protein receptors.
24S,25-epoxycholesterol
24S-hydroxycholesterol
G protein-coupled receptor
brain
cholesterol
nuclear receptor
oxysterol
Journal
British journal of pharmacology
ISSN: 1476-5381
Titre abrégé: Br J Pharmacol
Pays: England
ID NLM: 7502536
Informations de publication
Date de publication:
08 2021
08 2021
Historique:
revised:
16
06
2020
received:
16
04
2020
accepted:
21
06
2020
pubmed:
6
7
2020
medline:
22
9
2021
entrez:
5
7
2020
Statut:
ppublish
Résumé
The brain is the most cholesterol rich organ in the body containing about 25% of the body's free cholesterol. Cholesterol cannot pass the blood-brain barrier and be imported or exported; instead, it is synthesised in situ and metabolised to oxysterols, oxidised forms of cholesterol, which can pass the blood-brain barrier. 24S-Hydroxycholesterol is the dominant oxysterol in the brain after parturition, but during development, a myriad of other oxysterols are produced, which persist as minor oxysterols after birth. During both development and in later life, sterols and oxysterols interact with a variety of different receptors, including nuclear receptors, membrane bound GPCRs, the oxysterol/sterol sensing proteins INSIG and SCAP, and the ligand-gated ion channel NMDA receptors found in nerve cells. In this review, we summarise the different oxysterols and sterols found in the CNS whose biological activity is transmitted via these different classes of protein receptors. LINKED ARTICLES: This article is part of a themed issue on Oxysterols, Lifelong Health and Therapeutics. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v178.16/issuetoc.
Substances chimiques
Ligand-Gated Ion Channels
0
Ligands
0
Oxysterols
0
Receptors, Cytoplasmic and Nuclear
0
Sterols
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
3176-3193Subventions
Organisme : UK Biotechnology and Biological Sciences Research Council
ID : BB/I001735/1
Organisme : UK Biotechnology and Biological Sciences Research Council
ID : BB/L001942/1
Organisme : UK Biotechnology and Biological Sciences Research Council
ID : BB/N015932/1
Organisme : UK Biotechnology and Biological Sciences Research Council
ID : BB/S019588/1
Informations de copyright
© 2020 The Authors. British Journal of Pharmacology published by John Wiley & Sons Ltd on behalf of British Pharmacological Society.
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