The Intrinsically Disordered Protein CARP9 Bridges HYL1 to AGO1 in the Nucleus to Promote MicroRNA Activity.

Arabidopsis / genetics Arabidopsis Proteins / genetics Argonaute Proteins / genetics Cell Nucleus / metabolism Gene Expression Regulation, Plant Intrinsically Disordered Proteins / genetics RNA-Binding Proteins / genetics

Journal

Plant physiology
ISSN: 1532-2548
Titre abrégé: Plant Physiol
Pays: United States
ID NLM: 0401224

Informations de publication

Date de publication:
09 2020
Historique:
received: 27 03 2020
accepted: 22 06 2020
pubmed: 9 7 2020
medline: 22 6 2021
entrez: 9 7 2020
Statut: ppublish

Résumé

In plants, small RNAs are loaded into ARGONAUTE (AGO) proteins to fulfill their regulatory functions. MicroRNAs (miRNAs), one of the most abundant classes of endogenous small RNAs, are preferentially loaded into AGO1. Such loading, long believed to happen exclusively in the cytoplasm, was recently proposed to also occur in the nucleus. Here, we identified CONSTITUTIVE ALTERATIONS IN THE SMALL RNAS PATHWAYS9 (CARP9), a nuclear-localized, intrinsically disordered protein, as a factor promoting miRNA activity in Arabidopsis (

Identifiants

DOI: 10.1104/pp.20.00258 PMID: 32636339 PMC: PMC7479909
pubmed: 32636339
pii: pp.20.00258
doi: 10.1104/pp.20.00258
pmc: PMC7479909
doi:

Substances chimiques

AGO1 protein, Arabidopsis 0
Arabidopsis Proteins 0
Argonaute Proteins 0
HYL1 protein, Arabidopsis 0
Intrinsically Disordered Proteins 0
RNA-Binding Proteins 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

316-329

Informations de copyright

© 2020 American Society of Plant Biologists. All Rights Reserved.

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Auteurs

Ariel H Tomassi (AH)

Instituto de Agrobiotecnología del Litoral, Consejo Nacional de Investigaciones Científicas y Técnicas, Universidad Nacional del Litoral, Facultad de Bioquímica y Ciencias Biológicas, 3000 Santa Fe, Argentina.
ORCID: 0000-0001-7523-1776

Delfina A Re (DA)

Instituto de Agrobiotecnología del Litoral, Consejo Nacional de Investigaciones Científicas y Técnicas, Universidad Nacional del Litoral, Facultad de Bioquímica y Ciencias Biológicas, 3000 Santa Fe, Argentina.

Facundo Romani (F)

Instituto de Agrobiotecnología del Litoral, Consejo Nacional de Investigaciones Científicas y Técnicas, Universidad Nacional del Litoral, Facultad de Bioquímica y Ciencias Biológicas, 3000 Santa Fe, Argentina.
ORCID: 0000-0003-3954-6740

Damian A Cambiagno (DA)

Instituto de Agrobiotecnología del Litoral, Consejo Nacional de Investigaciones Científicas y Técnicas, Universidad Nacional del Litoral, Facultad de Bioquímica y Ciencias Biológicas, 3000 Santa Fe, Argentina.
ORCID: 0000-0001-9664-5900

Lucía Gonzalo (L)

Instituto de Agrobiotecnología del Litoral, Consejo Nacional de Investigaciones Científicas y Técnicas, Universidad Nacional del Litoral, Facultad de Bioquímica y Ciencias Biológicas, 3000 Santa Fe, Argentina.

Javier E Moreno (JE)

Instituto de Agrobiotecnología del Litoral, Consejo Nacional de Investigaciones Científicas y Técnicas, Universidad Nacional del Litoral, Facultad de Bioquímica y Ciencias Biológicas, 3000 Santa Fe, Argentina.
ORCID: 0000-0001-9763-5325

Agustin L Arce (AL)

Instituto de Agrobiotecnología del Litoral, Consejo Nacional de Investigaciones Científicas y Técnicas, Universidad Nacional del Litoral, Facultad de Bioquímica y Ciencias Biológicas, 3000 Santa Fe, Argentina.
ORCID: 0000-0003-3619-3898

Pablo A Manavella (PA)

Instituto de Agrobiotecnología del Litoral, Consejo Nacional de Investigaciones Científicas y Técnicas, Universidad Nacional del Litoral, Facultad de Bioquímica y Ciencias Biológicas, 3000 Santa Fe, Argentina pablomanavella@ial.santafe-conicet.gov.ar.
ORCID: 0000-0003-3589-4414

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Viridiplantae › Streptophyta › Embryophyta › Tracheobionta › Magnoliopsida › Brassicaceae › Arabidopsis › The Intrinsically Disordered Protein CARP9...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines végétales › Protéines d'Arabidopsis › The Intrinsically Disordered Protein CARP9...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Nucléoprotéines › Protéines de liaison à l'ARN › Ribonucléoprotéines › Complexe réprimant l'expression de l'ARN › Protéines Argonaute › The Intrinsically Disordered Protein CARP9...
questionsmedicales.fr › Cellules › Structures cellulaires › Espace intracellulaire › Cytoplasme › Structures cytoplasmiques › Organites › Noyau de la cellule › The Intrinsically Disordered Protein CARP9...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Régulation de l'expression des gènes végétaux › The Intrinsically Disordered Protein CARP9...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines intrinsèquement désordonnées › The Intrinsically Disordered Protein CARP9...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Nucléoprotéines › Protéines de liaison à l'ARN › The Intrinsically Disordered Protein CARP9...