Molecular evolution of the ATP-binding cassette subfamily G member 2 gene subfamily and its paralogs in birds.
ATP Binding Cassette Transporter, Subfamily G, Member 2
/ chemistry
Amino Acid Sequence
Animals
Birds
/ genetics
Chromosomes
/ genetics
Conserved Sequence
/ genetics
Evolution, Molecular
Exons
/ genetics
Gene Expression Regulation
Genome
Introns
/ genetics
Multigene Family
Open Reading Frames
/ genetics
Phosphorylation
Phylogeny
Protein Domains
RNA Splice Sites
/ genetics
Selection, Genetic
Sequence Homology, Amino Acid
Synteny
/ genetics
ABCG2
ABCG2-like
Birds
Chromosomal synteny
Gene duplication
Gene family evolution
Phylogeny
Selection pressures
Journal
BMC evolutionary biology
ISSN: 1471-2148
Titre abrégé: BMC Evol Biol
Pays: England
ID NLM: 100966975
Informations de publication
Date de publication:
14 07 2020
14 07 2020
Historique:
received:
15
02
2019
accepted:
07
07
2020
entrez:
16
7
2020
pubmed:
16
7
2020
medline:
17
9
2020
Statut:
epublish
Résumé
ATP-binding cassette (ABC) transporters are involved in the active transportation of various endogenous or exogenous substances. Two ABCG2 gene subfamily members have been identified in birds. A detailed comparative study of the ABCG2 and ABCG2-like genes aid our understanding of their evolutionary history at the molecular level and provide a theoretical reference for studying the specific functions of ABCG2 and ABCG2-like genes in birds. We first identified 77 ABCG2/ABCG2-like gene sequences in the genomes of 41 birds. Further analysis showed that both the nucleic acid and amino acid sequences of ABCG2 and ABCG2-like genes were highly conserved and exhibited high homology in birds. However, significant differences in the N-terminal structure were found between the ABCG2 and ABCG2-like amino acid sequences. A selective pressure analysis showed that the ABCG2 and ABCG2-like genes were affected by purifying selection during the process of bird evolution. We believe that multiple members of the ABCG2 gene subfamily exist on chromosome 4 in the ancestors of birds. Over the long course of evolution, only the ABCG2 gene was retained on chromosome 4 in birds. The ABCG2-like gene on chromosome 6 might have originated from chromosome replication or fusion. The structural differences between the N terminus of ABCG2 protein and those of ABCG2-like proteins might lead to functional differences between the corresponding genes.
Sections du résumé
BACKGROUND
ATP-binding cassette (ABC) transporters are involved in the active transportation of various endogenous or exogenous substances. Two ABCG2 gene subfamily members have been identified in birds. A detailed comparative study of the ABCG2 and ABCG2-like genes aid our understanding of their evolutionary history at the molecular level and provide a theoretical reference for studying the specific functions of ABCG2 and ABCG2-like genes in birds.
RESULTS
We first identified 77 ABCG2/ABCG2-like gene sequences in the genomes of 41 birds. Further analysis showed that both the nucleic acid and amino acid sequences of ABCG2 and ABCG2-like genes were highly conserved and exhibited high homology in birds. However, significant differences in the N-terminal structure were found between the ABCG2 and ABCG2-like amino acid sequences. A selective pressure analysis showed that the ABCG2 and ABCG2-like genes were affected by purifying selection during the process of bird evolution.
CONCLUSIONS
We believe that multiple members of the ABCG2 gene subfamily exist on chromosome 4 in the ancestors of birds. Over the long course of evolution, only the ABCG2 gene was retained on chromosome 4 in birds. The ABCG2-like gene on chromosome 6 might have originated from chromosome replication or fusion. The structural differences between the N terminus of ABCG2 protein and those of ABCG2-like proteins might lead to functional differences between the corresponding genes.
Identifiants
pubmed: 32664916
doi: 10.1186/s12862-020-01654-z
pii: 10.1186/s12862-020-01654-z
pmc: PMC7362505
doi:
Substances chimiques
ATP Binding Cassette Transporter, Subfamily G, Member 2
0
RNA Splice Sites
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
85Subventions
Organisme : National Natural Science Foundation of China
ID : 31872345
Pays : International
Organisme : Key Technology Support Program of Sichuan Province
ID : 2016NYZ0044
Pays : International
Organisme : Special Fund for Agro-scientific Research in the Public Interest (CN)
ID : CARS-43-6
Pays : International
Organisme : National Key R&D Program of China
ID : 2018YFD0501503-3
Pays : International
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