Ventral striatum regulates behavioral response to ethanol and MDMA combination.
Animals
Drug Combinations
Drug Synergism
Ethanol
/ administration & dosage
Locomotion
/ drug effects
Male
N-Methyl-3,4-methylenedioxyamphetamine
/ administration & dosage
Oxidopamine
/ pharmacology
Rats
Rats, Long-Evans
Receptors, Dopamine D1
/ antagonists & inhibitors
Receptors, N-Methyl-D-Aspartate
/ antagonists & inhibitors
Tetrodotoxin
/ pharmacology
Ventral Striatum
/ drug effects
3,4-methylenedioxymethamphetamine
dopamine D1 receptors
ecstasy
ethanol
rat
ventral striatum
Journal
Addiction biology
ISSN: 1369-1600
Titre abrégé: Addict Biol
Pays: United States
ID NLM: 9604935
Informations de publication
Date de publication:
03 2021
03 2021
Historique:
received:
15
01
2020
revised:
20
05
2020
accepted:
29
06
2020
pubmed:
16
7
2020
medline:
19
1
2022
entrez:
16
7
2020
Statut:
ppublish
Résumé
Our previous studies consistently showed that MDMA-induced locomotor hyperactivity is dramatically increased by coadministration of ethanol (EtOH) in rats, indicating possible potentiation of MDMA abuse liability. Thus, we aimed to identify the brain region(s) and neuropharmacological substrates involved in the pharmacodynamics of this potentiation. We first showed that potentiation of locomotor activity by the combination of ip administration of EtOH (1.5 g/kg) and MDMA (6.6 mg/kg) is delay sensitive and maximal when both drugs are injected simultaneously. Then, we used the 2-deoxyglucose quantitative autoradiography technique to assess the impact of EtOH, MDMA, or their combination on local cerebral metabolic rates for glucose (CMRglcs). We showed a specific metabolic activation in the ventral striatum (VS) under MDMA + EtOH versus MDMA or EtOH alone. We next tested if reversible (tetrodotoxin, TTX) or permanent (6-hydrodoxyopamine, 6-OHDA) lesion of the VS could affect locomotor response to MDMA and MDMA + EtOH. Finally, we blocked dopamine D1 or glutamate NMDA receptors in the VS and measured the effects of MDMA and MDMA + EtOH on locomotor activity. We showed that bilateral reversible inactivation (TTX) or permanent lesion (6-OHDA) of the VS prevented the potentiation by EtOH of MDMA-induced locomotor hyperactivity. Likewise, blockade of D1 or NMDA receptors in the VS also reduced the potentiation of MDMA locomotor activity by EtOH. These data indicate that dopamine D1 and glutamate NMDA receptor-driven mechanisms in the VS play a key role in the pharmacodynamics of EtOH-induced potentiation of the locomotor effects of MDMA.
Substances chimiques
Drug Combinations
0
Receptors, Dopamine D1
0
Receptors, N-Methyl-D-Aspartate
0
Ethanol
3K9958V90M
Tetrodotoxin
4368-28-9
Oxidopamine
8HW4YBZ748
N-Methyl-3,4-methylenedioxyamphetamine
KE1SEN21RM
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e12938Informations de copyright
© 2020 Society for the Study of Addiction.
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