RNA-Seq Transcriptome Analysis Reveals Long Terminal Repeat Retrotransposon Modulation in Human Peripheral Blood Mononuclear Cells after
Endogenous Retroviruses
/ genetics
Gene Expression Profiling
/ methods
Genome, Human
Humans
Injections
Leukocytes, Mononuclear
/ drug effects
Lipopolysaccharides
/ administration & dosage
Proviruses
/ genetics
RNA-Seq
/ methods
Retroelements
/ genetics
Terminal Repeat Sequences
/ genetics
Transcriptome
/ drug effects
HERV
LPS
MaLR
PBMCs
RNA-Seq
human
immunity
Journal
Journal of virology
ISSN: 1098-5514
Titre abrégé: J Virol
Pays: United States
ID NLM: 0113724
Informations de publication
Date de publication:
15 09 2020
15 09 2020
Historique:
received:
01
04
2020
accepted:
07
07
2020
pubmed:
17
7
2020
medline:
22
12
2020
entrez:
17
7
2020
Statut:
epublish
Résumé
Human endogenous retroviruses (HERVs) and mammalian apparent long terminal repeat (LTR) retrotransposons (MaLRs) are retroviral sequences that integrated into germ line cells millions of years ago. Transcripts of these LTR retrotransposons are present in several tissues, and their expression is modulated in pathological conditions, although their function remains often far from being understood. Here, we focused on the HERV/MaLR expression and modulation in a scenario of immune system activation. We used a public data set of human peripheral blood mononuclear cells (PBMCs) RNA-Seq from 15 healthy participants to a clinical trial before and after exposure to lipopolysaccharide (LPS), for which we established an RNA-Seq workflow for the identification of expressed and modulated cellular genes and LTR retrotransposon elements.
Identifiants
pubmed: 32669333
pii: JVI.00587-20
doi: 10.1128/JVI.00587-20
pmc: PMC7495373
pii:
doi:
Substances chimiques
Lipopolysaccharides
0
Retroelements
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright © 2020 American Society for Microbiology.
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