Meta-Analysis of Leukocyte Diversity in Atherosclerotic Mouse Aortas.
T lymphocytes
atherosclerosis
interferons
macrophages
monocytes
mouse
neutrophils
Journal
Circulation research
ISSN: 1524-4571
Titre abrégé: Circ Res
Pays: United States
ID NLM: 0047103
Informations de publication
Date de publication:
17 07 2020
17 07 2020
Historique:
entrez:
17
7
2020
pubmed:
17
7
2020
medline:
25
5
2021
Statut:
ppublish
Résumé
The diverse leukocyte infiltrate in atherosclerotic mouse aortas was recently analyzed in 9 single-cell RNA sequencing and 2 mass cytometry studies. In a comprehensive meta-analysis, we confirm 4 known macrophage subsets-resident, inflammatory, interferon-inducible cell, and Trem2 (triggering receptor expressed on myeloid cells-2) foamy macrophages-and identify a new macrophage subset resembling cavity macrophages. We also find that monocytes, neutrophils, dendritic cells, natural killer cells, innate lymphoid cells-2, and CD (cluster of differentiation)-8 T cells form prominent and separate immune cell populations in atherosclerotic aortas. Many CD4 T cells express IL (interleukin)-17 and the chemokine receptor CXCR (C-X-C chemokine receptor)-6. A small number of regulatory T cells and T helper 1 cells is also identified. Immature and naive T cells are present in both healthy and atherosclerotic aortas. Our meta-analysis overcomes limitations of individual studies that, because of their experimental approach, over- or underrepresent certain cell populations. Mass cytometry studies demonstrate that cell surface phenotype provides valuable information beyond the cell transcriptomes. The present analysis helps resolve some long-standing controversies in the field. First, Trem2
Identifiants
pubmed: 32673538
doi: 10.1161/CIRCRESAHA.120.316903
pmc: PMC7371244
mid: NIHMS1600990
doi:
Substances chimiques
Biomarkers
0
Types de publication
Journal Article
Meta-Analysis
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
402-426Subventions
Organisme : NHLBI NIH HHS
ID : R00 HL138163
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL139000
Pays : United States
Organisme : NHLBI NIH HHS
ID : R35 HL145241
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA202987
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL140976
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL136098
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL148094
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL137229
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL146134
Pays : United States
Organisme : NHLBI NIH HHS
ID : P01 HL136275
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL142129
Pays : United States
Organisme : NHLBI NIH HHS
ID : P01 HL055798
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL134236
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL141853
Pays : United States
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