Cell Types Promoting Goosebumps Form a Niche to Regulate Hair Follicle Stem Cells.

Accessory Nerve / cytology Animals Cell Cycle / genetics Cold Temperature Female Fibroblast Growth Factors / metabolism Forkhead Transcription Factors / metabolism Gene Expression Profiling Hair / cytology Hair Follicle / cytology Hedgehog Proteins / metabolism Humans Male Mice Mice, Inbred C57BL Norepinephrine / metabolism Piloerection RNA-Seq Receptors, Adrenergic, beta-2 / deficiency Repressor Proteins / metabolism Signal Transduction / drug effects Smoothened Receptor / genetics Stem Cell Niche Stem Cells / cytology Sympathetic Nervous System / cytology Synapses / physiology
Adrb2 hair follicle stem cells nerve-stem-cell interaction niche stem cell quiescence sympathetic nerve

Journal

Cell
ISSN: 1097-4172
Titre abrégé: Cell
Pays: United States
ID NLM: 0413066

Informations de publication

Date de publication:
06 08 2020
Historique:
received: 22 04 2019
revised: 06 04 2020
accepted: 18 06 2020
pubmed: 18 7 2020
medline: 30 3 2021
entrez: 18 7 2020
Statut: ppublish

Résumé

Piloerection (goosebumps) requires concerted actions of the hair follicle, the arrector pili muscle (APM), and the sympathetic nerve, providing a model to study interactions across epithelium, mesenchyme, and nerves. Here, we show that APMs and sympathetic nerves form a dual-component niche to modulate hair follicle stem cell (HFSC) activity. Sympathetic nerves form synapse-like structures with HFSCs and regulate HFSCs through norepinephrine, whereas APMs maintain sympathetic innervation to HFSCs. Without norepinephrine signaling, HFSCs enter deep quiescence by down-regulating the cell cycle and metabolism while up-regulating quiescence regulators Foxp1 and Fgf18. During development, HFSC progeny secretes Sonic Hedgehog (SHH) to direct the formation of this APM-sympathetic nerve niche, which in turn controls hair follicle regeneration in adults. Our results reveal a reciprocal interdependence between a regenerative tissue and its niche at different stages and demonstrate sympathetic nerves can modulate stem cells through synapse-like connections and neurotransmitters to couple tissue production with demands.

Identifiants

DOI: 10.1016/j.cell.2020.06.031 PMID: 32679029 PMC: PMC7540726
pubmed: 32679029
pii: S0092-8674(20)30808-4
doi: 10.1016/j.cell.2020.06.031
pmc: PMC7540726
mid: NIHMS1607799
pii:
doi:

Substances chimiques

ADRB2 protein, mouse 0
Forkhead Transcription Factors 0
Foxp1 protein, mouse 0
Hedgehog Proteins 0
Receptors, Adrenergic, beta-2 0
Repressor Proteins 0
Smo protein, mouse 0
Smoothened Receptor 0
fibroblast growth factor 18 0
Fibroblast Growth Factors 62031-54-3
Norepinephrine X4W3ENH1CV

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

578-593.e19

Subventions

Organisme : NIDDK NIH HHS
ID : P30 DK036836
Pays : United States
Organisme : NIAMS NIH HHS
ID : R01 AR070825
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK077097
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK102898
Pays : United States

Commentaires et corrections

Type : CommentIn

Informations de copyright

Copyright © 2020 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Interests A provisional patent application has been filed by the President and Fellows of Harvard College based on this work.

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Auteurs

Yulia Shwartz (Y)

Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA.

Meryem Gonzalez-Celeiro (M)

Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA; Institute of Molecular Health Sciences, ETH Zurich, 8093 Zurich, Switzerland.

Chih-Lung Chen (CL)

Department of Biomedical Engineering, College of Medicine and College of Engineering, National Taiwan University, Taipei 100, Taiwan.

H Amalia Pasolli (HA)

Electron Microscopy Resource Center, The Rockefeller University, New York, NY 10065, USA.

Shu-Hsien Sheu (SH)

Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA 20147, USA.

Sabrina Mai-Yi Fan (SM)

Department of Biomedical Engineering, College of Medicine and College of Engineering, National Taiwan University, Taipei 100, Taiwan.

Farnaz Shamsi (F)

Section on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA.

Steven Assaad (S)

Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA.

Edrick Tai-Yu Lin (ET)

Department of Biomedical Engineering, College of Medicine and College of Engineering, National Taiwan University, Taipei 100, Taiwan.

Bing Zhang (B)

Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA.

Pai-Chi Tsai (PC)

Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA.

Megan He (M)

Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA; Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA.

Yu-Hua Tseng (YH)

Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA; Section on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA.

Sung-Jan Lin (SJ)

Department of Biomedical Engineering, College of Medicine and College of Engineering, National Taiwan University, Taipei 100, Taiwan; Department of Dermatology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei 100, Taiwan; Research Center for Developmental Biology and Regenerative Medicine, National Taiwan University, Taipei 100, Taiwan; Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei 100, Taiwan. Electronic address: drsjlin@ntu.edu.tw.

Ya-Chieh Hsu (YC)

Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA. Electronic address: yachieh_hsu@harvard.edu.

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Classifications MeSH

questionsmedicales.fr › Système nerveux › Système nerveux périphérique › Nerfs périphériques › Nerfs crâniens › Nerf accessoire › Cell Types Promoting Goosebumps Form a Niche...
questionsmedicales.fr › Eucaryotes › Animaux › Cell Types Promoting Goosebumps Form a Niche...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Cycle cellulaire › Cell Types Promoting Goosebumps Form a Niche...
questionsmedicales.fr › Environnement et santé publique › Environnement › Concepts météorologiques › Atmosphère › Temps (météorologie) › Température › Basse température › Cell Types Promoting Goosebumps Form a Niche...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Facteurs de croissance fibroblastique › Cell Types Promoting Goosebumps Form a Niche...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de transcription à motif hélice ailée › Facteurs de transcription Forkhead › Cell Types Promoting Goosebumps Form a Niche...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Analyse de profil d'expression de gènes › Cell Types Promoting Goosebumps Form a Niche...
questionsmedicales.fr › Système tégumentaire › Poils › Cell Types Promoting Goosebumps Form a Niche...
questionsmedicales.fr › Système tégumentaire › Peau › Épiderme › Follicule pileux › Cell Types Promoting Goosebumps Form a Niche...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Protéines Hedgehog › Cell Types Promoting Goosebumps Form a Niche...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Cell Types Promoting Goosebumps Form a Niche...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Cell Types Promoting Goosebumps Form a Niche...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Cell Types Promoting Goosebumps Form a Niche...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures cycliques › Hydrocarbures aromatiques › Dérivés du benzène › Phénols › Catéchols › Catécholamines › Norépinéphrine › Cell Types Promoting Goosebumps Form a Niche...
questionsmedicales.fr › Phénomènes physiologiques du système tégumentaire › Phénomènes physiologiques de la peau › Horripilation › Cell Types Promoting Goosebumps Form a Niche...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Analyse de séquence › Analyse de séquence d'ARN › RNA-Seq › Cell Types Promoting Goosebumps Form a Niche...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs aux neuromédiateurs › Récepteurs catécholaminergiques › Récepteurs adrénergiques › Récepteurs bêta-adrénergiques › Récepteurs bêta-2 adrénergiques › Cell Types Promoting Goosebumps Form a Niche...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Protéines de répression › Cell Types Promoting Goosebumps Form a Niche...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Cell Types Promoting Goosebumps Form a Niche...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs Wnt › Récepteurs Frizzled › Récepteur Smoothened › Cell Types Promoting Goosebumps Form a Niche...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Microenvironnement cellulaire › Niche de cellules souches › Cell Types Promoting Goosebumps Form a Niche...
questionsmedicales.fr › Cellules › Cellules souches › Cell Types Promoting Goosebumps Form a Niche...
questionsmedicales.fr › Système nerveux › Système nerveux périphérique › Système nerveux autonome › Système nerveux sympathique › Cell Types Promoting Goosebumps Form a Niche...
questionsmedicales.fr › Cellules › Structures cellulaires › Membrane cellulaire › Structures de la membrane cellulaire › Jonctions intercellulaires › Synapses › Cell Types Promoting Goosebumps Form a Niche...