Systolic-dicrotic notch pressure difference can identify tachycardic patients with septic shock at risk of cardiovascular decompensation following pharmacological heart rate reduction.
Adrenergic beta-Antagonists
/ therapeutic use
Adult
Aged
Arterial Pressure
Blood Pressure
/ drug effects
Cardiac Output
/ drug effects
Echocardiography
Female
Heart Failure
/ diagnostic imaging
Heart Rate
/ drug effects
Humans
Male
Middle Aged
Myocardial Contraction
/ drug effects
Norepinephrine
/ therapeutic use
Propanolamines
/ therapeutic use
Prospective Studies
Shock, Septic
/ diagnostic imaging
Tachycardia
/ diagnostic imaging
Vasoconstrictor Agents
/ therapeutic use
arterial elastance
beta blockers
dicrotic notch
esmolol
haemodynamic monitoring
septic shock
tachycardia
ventricular–arterial coupling
Journal
British journal of anaesthesia
ISSN: 1471-6771
Titre abrégé: Br J Anaesth
Pays: England
ID NLM: 0372541
Informations de publication
Date de publication:
12 2020
12 2020
Historique:
received:
17
03
2020
revised:
27
05
2020
accepted:
28
05
2020
pubmed:
22
7
2020
medline:
15
12
2020
entrez:
22
7
2020
Statut:
ppublish
Résumé
During sepsis, heart rate (HR) reduction could be a therapeutic target, but identification of responders (non-compensatory tachycardia) and non-responders (compensatory for 'fixed' stroke volume [SV]) is challenging. We tested the ability of the difference between systolic and dicrotic pressure (SDP In this post hoc analysis of 45 patients with septic shock with persistent tachycardia, we characterised features of haemodynamic response focusing on SDP After reducing HR, arterial dP/dt A decrease in SDP NCT02188888.
Sections du résumé
BACKGROUND
During sepsis, heart rate (HR) reduction could be a therapeutic target, but identification of responders (non-compensatory tachycardia) and non-responders (compensatory for 'fixed' stroke volume [SV]) is challenging. We tested the ability of the difference between systolic and dicrotic pressure (SDP
METHODS
In this post hoc analysis of 45 patients with septic shock with persistent tachycardia, we characterised features of haemodynamic response focusing on SDP
RESULTS
After reducing HR, arterial dP/dt
CONCLUSIONS
A decrease in SDP
CLINICAL TRIAL REGISTRATION
NCT02188888.
Identifiants
pubmed: 32690246
pii: S0007-0912(20)30446-3
doi: 10.1016/j.bja.2020.05.058
pii:
doi:
Substances chimiques
Adrenergic beta-Antagonists
0
Propanolamines
0
Vasoconstrictor Agents
0
esmolol
MDY902UXSR
Norepinephrine
X4W3ENH1CV
Banques de données
ClinicalTrials.gov
['NCT02188888']
Types de publication
Journal Article
Observational Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
1018-1024Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2020 British Journal of Anaesthesia. Published by Elsevier Ltd. All rights reserved.