Neonatal genetics of gene expression reveal potential origins of autoimmune and allergic disease risk.
Autoimmune Diseases
/ genetics
Butyrophilins
/ genetics
CD4-Positive T-Lymphocytes
/ immunology
Cathepsin H
/ genetics
Child
Child Development
/ physiology
Child, Preschool
Datasets as Topic
Fetal Blood
/ cytology
Gene Expression Profiling
Gene Expression Regulation, Developmental
/ immunology
Gene Regulatory Networks
/ immunology
Genetic Predisposition to Disease
Genome-Wide Association Study
HLA-C Antigens
/ genetics
Humans
Hypersensitivity
/ genetics
Infant
Infant, Newborn
Mendelian Randomization Analysis
Myeloid Cells
/ immunology
Oligonucleotide Array Sequence Analysis
Polymorphism, Single Nucleotide
Prospective Studies
Quantitative Trait Loci
/ immunology
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
28 07 2020
28 07 2020
Historique:
received:
23
07
2019
accepted:
29
06
2020
entrez:
30
7
2020
pubmed:
30
7
2020
medline:
22
9
2020
Statut:
epublish
Résumé
Chronic immune-mediated diseases of adulthood often originate in early childhood. To investigate genetic associations between neonatal immunity and disease, we map expression quantitative trait loci (eQTLs) in resting myeloid cells and CD4
Identifiants
pubmed: 32724101
doi: 10.1038/s41467-020-17477-x
pii: 10.1038/s41467-020-17477-x
pmc: PMC7387553
doi:
Substances chimiques
BTN3A2 protein, human
0
Butyrophilins
0
HLA-C Antigens
0
CTSH protein, human
EC 3.4.22.16
Cathepsin H
EC 3.4.22.16
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3761Subventions
Organisme : Medical Research Council
ID : MR/L003120/1
Pays : United Kingdom
Organisme : Department of Health
Pays : United Kingdom
Organisme : British Heart Foundation
ID : RG/18/13/33946
Pays : United Kingdom
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Chief Scientist Office
Pays : United Kingdom
Organisme : British Heart Foundation
ID : RG/13/13/30194
Pays : United Kingdom
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