Characterization of metabolites in Saposhnikovia divaricata root from Mongolia.
1H NMR
HPLC–DAD
Mongolia
Multivariate statistical analysis
Saposhnikovia divaricata
Saposhnikoviae Radix
Journal
Journal of natural medicines
ISSN: 1861-0293
Titre abrégé: J Nat Med
Pays: Japan
ID NLM: 101518405
Informations de publication
Date de publication:
Jan 2021
Jan 2021
Historique:
received:
16
05
2020
accepted:
25
06
2020
pubmed:
3
8
2020
medline:
23
2
2021
entrez:
3
8
2020
Statut:
ppublish
Résumé
Saposhnikoviae Radix (SR), derived from the dried root and rhizome of Saposhnikovia divaricata, is a popular crude drug used in traditional Chinese and Japanese medicine. To evaluate the metabolites of S. divaricata roots from Mongolia and to investigate their geographical variation, we developed the HPLC method, determined the contents of 9 chromones and 4 coumarins, and conducted multivariate statistical analysis. All Mongolian specimens contained prim-O-glucosylcimifugin (1) and 4'-O-β-D-glucosyl-5-O-methylvisamminol (3), and their total amount (5.04-25.06 mg/g) exceeded the criterion assigned in the Chinese Pharmacopoeia. Moreover, the content of 1 (3.98-20.79 mg/g) was significantly higher in the Mongolian specimens than in Chinese SR samples. The specimens from Norovlin showed the highest contents of 1 and 3. The total levels of dihydropyranochromones were higher in the specimens from Bayan-Uul. The orthogonal partial least squares-discriminant analysis revealed that the Mongolian specimens tended to be separated into three groups based on growing regions, in which several chromones contributed to each distribution. Furthermore,
Identifiants
pubmed: 32740706
doi: 10.1007/s11418-020-01430-9
pii: 10.1007/s11418-020-01430-9
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
11-27Subventions
Organisme : Japan Society for the Promotion of Science
ID : 15H05268
Organisme : Japan Society for the Promotion of Science
ID : 24406005
Organisme : Japan Society for the Promotion of Science
ID : 15K07993
Organisme : Japan Society for the Promotion of Science
ID : 18K06728
Organisme : Japan Agency for Medical Research and Development
ID : JP17ak0101046h0002
Organisme : Japan Agency for Medical Research and Development
ID : JP18ak0101046h0003
Organisme : Japan Agency for Medical Research and Development
ID : JP19ak0101046h0004
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