ALKBH5 regulates anti-PD-1 therapy response by modulating lactate and suppressive immune cell accumulation in tumor microenvironment.

AlkB Homolog 5, RNA Demethylase / genetics Antibodies Cancer Vaccines / immunology Cytokines / genetics Gene Deletion Gene Expression Regulation, Neoplastic Humans Lactates / metabolism Melanoma / metabolism Methyltransferases / genetics Monocarboxylic Acid Transporters / genetics Muscle Proteins / genetics Myeloid-Derived Suppressor Cells / physiology Programmed Cell Death 1 Receptor / immunology RNA Splice Sites RNA Splicing Symporters / genetics T-Lymphocytes, Regulatory / physiology Transcriptome Tumor Microenvironment Vascular Endothelial Growth Factor A / genetics
GVAX PD-1 blockade immunotherapy enhancers m6A RNA modification melanoma

Journal

Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876

Informations de publication

Date de publication:
18 08 2020
Historique:
pubmed: 5 8 2020
medline: 7 10 2020
entrez: 5 8 2020
Statut: ppublish

Résumé

Although immune checkpoint blockade (ICB) therapy has revolutionized cancer treatment, many patients do not respond or develop resistance to ICB.

Identifiants

DOI: 10.1073/pnas.1918986117 PMID: 32747553 PMC: PMC7443867
pubmed: 32747553
pii: 1918986117
doi: 10.1073/pnas.1918986117
pmc: PMC7443867
doi:

Substances chimiques

Antibodies 0
Cancer Vaccines 0
Cytokines 0
GVAX vaccine 0
Lactates 0
Monocarboxylic Acid Transporters 0
Muscle Proteins 0
PDCD1 protein, human 0
Programmed Cell Death 1 Receptor 0
RNA Splice Sites 0
SLC16A3 protein, human 0
SLC16A4 protein, human 0
Symporters 0
Vascular Endothelial Growth Factor A 0
ALKBH5 protein, human EC 1.14.11.-
AlkB Homolog 5, RNA Demethylase EC 1.14.11.-
Methyltransferases EC 2.1.1.-
METTL3 protein, human EC 2.1.1.62

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

20159-20170

Subventions

Organisme : NIDA NIH HHS
ID : R01 DA046171
Pays : United States
Organisme : NIDA NIH HHS
ID : DP1 DA039562
Pays : United States
Organisme : NIH HHS
ID : S10 OD026929
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA023100
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI125103
Pays : United States
Organisme : NCI NIH HHS
ID : P01 CA177322
Pays : United States

Informations de copyright

Copyright © 2020 the Author(s). Published by PNAS.

Déclaration de conflit d'intérêts

T.M.R. is a founder of ViRx Pharmaceuticals and has an equity interest in the company. The terms of this arrangement have been reviewed and approved by the University of California San Diego in accordance with its conflict of interest policies.

Références

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Auteurs

Na Li (N)

Division of Genetics, Department of Pediatrics, Program in Immunology, Institute for Genomic Medicine, University of California San Diego, La Jolla, CA 92093.
ORCID: 0000-0002-2852-8099

Yuqi Kang (Y)

Division of Genetics, Department of Pediatrics, Program in Immunology, Institute for Genomic Medicine, University of California San Diego, La Jolla, CA 92093.
Bioinformatics Program, University of California San Diego, La Jolla, CA 92093.

Lingling Wang (L)

Division of Genetics, Department of Pediatrics, Program in Immunology, Institute for Genomic Medicine, University of California San Diego, La Jolla, CA 92093.

Sarah Huff (S)

Division of Genetics, Department of Pediatrics, Program in Immunology, Institute for Genomic Medicine, University of California San Diego, La Jolla, CA 92093.

Rachel Tang (R)

Division of Genetics, Department of Pediatrics, Program in Immunology, Institute for Genomic Medicine, University of California San Diego, La Jolla, CA 92093.

Hui Hui (H)

Division of Genetics, Department of Pediatrics, Program in Immunology, Institute for Genomic Medicine, University of California San Diego, La Jolla, CA 92093.
Bioinformatics Program, University of California San Diego, La Jolla, CA 92093.

Kriti Agrawal (K)

Division of Genetics, Department of Pediatrics, Program in Immunology, Institute for Genomic Medicine, University of California San Diego, La Jolla, CA 92093.
Bioinformatics Program, University of California San Diego, La Jolla, CA 92093.

Gwendolyn Michelle Gonzalez (GM)

Environmental Toxicology Graduate Program, University of California, Riverside, CA 92521.
Department of Chemistry, University of California, Riverside, CA 92521.

Yinsheng Wang (Y)

Environmental Toxicology Graduate Program, University of California, Riverside, CA 92521.
Department of Chemistry, University of California, Riverside, CA 92521.

Sandip Pravin Patel (SP)

San Diego Center for Precision Immunotherapy, Moores Cancer Center, University of California San Diego, La Jolla, CA 92093.

Tariq M Rana (TM)

Division of Genetics, Department of Pediatrics, Program in Immunology, Institute for Genomic Medicine, University of California San Diego, La Jolla, CA 92093; trana@ucsd.edu.
San Diego Center for Precision Immunotherapy, Moores Cancer Center, University of California San Diego, La Jolla, CA 92093.

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Classifications MeSH

questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Oxygénases › Dioxygenases › AlkB enzymes › AlkB Homolog 5, RNA demethylase › ALKBH5 regulates anti-PD-1 therapy response by...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › ALKBH5 regulates anti-PD-1 therapy response by...
questionsmedicales.fr › Mélanges complexes › Produits biologiques › Vaccins › Vaccins anticancéreux › ALKBH5 regulates anti-PD-1 therapy response by...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › ALKBH5 regulates anti-PD-1 therapy response by...
questionsmedicales.fr › Phénomènes génétiques › Mutagenèse › Délétion de séquence › Délétion de gène › ALKBH5 regulates anti-PD-1 therapy response by...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Régulation de l'expression des gènes tumoraux › ALKBH5 regulates anti-PD-1 therapy response by...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › ALKBH5 regulates anti-PD-1 therapy response by...
questionsmedicales.fr › Composés chimiques organiques › Acides carboxyliques › Hydroxyacides › Lactates › ALKBH5 regulates anti-PD-1 therapy response by...
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Naevus et mélanomes › Mélanome › ALKBH5 regulates anti-PD-1 therapy response by...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › One-carbon group transferases › Methyltransferases › ALKBH5 regulates anti-PD-1 therapy response by...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Pompes ioniques › Transporteurs d'anions › Transporteurs d'anions organiques › Transporteurs d'acides monocarboxyliques › ALKBH5 regulates anti-PD-1 therapy response by...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines contractiles › Protéines du muscle › ALKBH5 regulates anti-PD-1 therapy response by...
questionsmedicales.fr › Cellules › Cellules myéloïdes › Cellules myéloïdes suppressives › ALKBH5 regulates anti-PD-1 therapy response by...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Antigènes de différenciation › Antigènes de différenciation des lymphocytes T › Récepteur-1 de mort cellulaire programmée › ALKBH5 regulates anti-PD-1 therapy response by...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Gènes › Composants de gène › Sites d'épissage d'ARN › ALKBH5 regulates anti-PD-1 therapy response by...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Maturation post-transcriptionnelle des ARN › Épissage des ARN › ALKBH5 regulates anti-PD-1 therapy response by...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Pompes ioniques › Symporteurs › ALKBH5 regulates anti-PD-1 therapy response by...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Sous-populations de lymphocytes T › Lymphocytes T régulateurs › ALKBH5 regulates anti-PD-1 therapy response by...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Transcriptome › ALKBH5 regulates anti-PD-1 therapy response by...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Microenvironnement cellulaire › Microenvironnement tumoral › ALKBH5 regulates anti-PD-1 therapy response by...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Protéines angiogéniques › Facteurs de croissance endothéliale vasculaire › Facteur de croissance endothéliale vasculaire de type A › ALKBH5 regulates anti-PD-1 therapy response by...