Genetic associations of single nucleotide polymorphisms in the l-DOPA receptor (GPR143) gene with severity of nicotine dependence in Japanese individuals, and attenuation of nicotine reinforcement in Gpr143 gene-deficient mice.
Animals
Asian People
Eye Proteins
/ genetics
Gene Deletion
Genetic Association Studies
Humans
Male
Membrane Glycoproteins
/ genetics
Mice, Inbred C57BL
Mice, Knockout
Nicotine
/ adverse effects
Polymorphism, Single Nucleotide
Receptors, G-Protein-Coupled
/ genetics
Receptors, Neurotransmitter
/ genetics
Reinforcement, Psychology
Severity of Illness Index
Substance-Related Disorders
/ genetics
Addiction
GPR143
Nicotine
Polymorphism
Journal
Journal of pharmacological sciences
ISSN: 1347-8648
Titre abrégé: J Pharmacol Sci
Pays: Japan
ID NLM: 101167001
Informations de publication
Date de publication:
Oct 2020
Oct 2020
Historique:
received:
05
09
2019
revised:
21
04
2020
accepted:
11
05
2020
pubmed:
9
8
2020
medline:
7
10
2020
entrez:
9
8
2020
Statut:
ppublish
Résumé
l-3,4-dihydroxyphenylalanine (l-DOPA) is a candidate neurotransmitter. l-DOPA is released by nicotine through nicotinic receptors. Recently, G-protein coupled receptor GPR143, was identified as a receptor for l-DOPA. In this study, genetic association studies between GPR143 genetic polymorphisms and smoking behaviors revealed that the single-nucleotide polymorphism rs6640499, in the GPR143 gene, was associated with traits of smoking behaviors in Japanese individuals. In Gpr143 gene-deficient mice, nicotine-induced hypolocomotion and rewarding effect were attenuated compared to those in wild-type mice. Our findings suggest the involvement of GPR143 in the smoking behaviors.
Identifiants
pubmed: 32763057
pii: S1347-8613(20)30067-0
doi: 10.1016/j.jphs.2020.07.003
pii:
doi:
Substances chimiques
Eye Proteins
0
GPR143 protein, human
0
Gpr143 protein, mouse
0
Membrane Glycoproteins
0
Receptors, G-Protein-Coupled
0
Receptors, Neurotransmitter
0
levodopa receptor
0
Nicotine
6M3C89ZY6R
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
89-93Informations de copyright
Copyright © 2020 The Authors. Production and hosting by Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that there are no conflicts of interest.