Altered Regulatory B Cell Subsets in Children with Type 1 Diabetes Mellitus.
ADP-ribosyl Cyclase 1
/ immunology
Autoantibodies
/ immunology
Autoimmune Diseases
/ immunology
B-Lymphocytes, Regulatory
/ immunology
Blood Glucose
/ immunology
CD24 Antigen
/ immunology
Child
Child, Preschool
Diabetes Mellitus, Type 1
/ immunology
Female
Humans
Immune Tolerance
/ immunology
Inflammation
/ immunology
Interleukin-10
/ immunology
Islets of Langerhans
/ immunology
Male
Tumor Necrosis Factor Receptor Superfamily, Member 7
/ immunology
Journal
Journal of immunology research
ISSN: 2314-7156
Titre abrégé: J Immunol Res
Pays: Egypt
ID NLM: 101627166
Informations de publication
Date de publication:
2020
2020
Historique:
received:
23
04
2020
revised:
24
06
2020
accepted:
04
07
2020
entrez:
11
8
2020
pubmed:
11
8
2020
medline:
5
6
2021
Statut:
epublish
Résumé
B regulatory cells (Breg) refer to characteristic subsets of B cells that generally exert anti-inflammatory functions and maintain peripheral tolerance mainly through their ability to secrete interleukin-10 (IL10). Dysregulation in the function of Breg cells was reported in several autoimmune diseases. However, the relation between Breg and children with type 1 diabetes (T1D) is poorly understood. Thus, this study is aimed at determining whether Breg cells play a role in T1D in children or not, so we hypothesized that an altered phenotype of B cell subsets is associated with T1D in children. Children with T1D (
Identifiants
pubmed: 32775471
doi: 10.1155/2020/8935694
pmc: PMC7391103
doi:
Substances chimiques
Autoantibodies
0
Blood Glucose
0
CD24 Antigen
0
Tumor Necrosis Factor Receptor Superfamily, Member 7
0
Interleukin-10
130068-27-8
ADP-ribosyl Cyclase 1
EC 3.2.2.6
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
8935694Informations de copyright
Copyright © 2020 Mohamed A. El-Mokhtar et al.
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
Références
Diabetes. 2008 Nov;57(11):3013-24
pubmed: 18689692
J Immunol. 2010 Aug 15;185(4):2240-52
pubmed: 20624940
Diabetes Care. 2014 Feb;37(2):453-9
pubmed: 24026563
Immunity. 2014 Dec 18;41(6):1040-51
pubmed: 25484301
Adv Data. 2000 Jun 8;(314):1-27
pubmed: 11183293
Arthritis Res Ther. 2012 Feb 08;14(1):R32
pubmed: 22315945
Mediators Inflamm. 2017;2017:8415094
pubmed: 28831210
Diabetes Care. 2016 Mar;39(3):434-40
pubmed: 26721817
J Immunol. 1998 Oct 15;161(8):3912-8
pubmed: 9780157
Diabet Med. 1998 Jul;15(7):539-53
pubmed: 9686693
J Clin Invest. 2007 Dec;117(12):3857-67
pubmed: 18060033
Cell Physiol Biochem. 2015;36(6):2161-9
pubmed: 26279423
J Autoimmun. 2014 Nov;54:33-50
pubmed: 25175979
Ann Neurol. 2008 Aug;64(2):187-99
pubmed: 18655096
Blood. 2011 Jan 13;117(2):530-41
pubmed: 20962324
Arthritis Rheum. 1994 Nov;37(11):1647-55
pubmed: 7980676
Immunity. 2010 Jan 29;32(1):129-40
pubmed: 20079667
Clin Exp Immunol. 2014 Sep;177(3):571-85
pubmed: 24773525
Clin Exp Immunol. 2010 Nov;162(2):271-9
pubmed: 20854328
Nat Rev Rheumatol. 2010 Nov;6(11):636-43
pubmed: 20856268
J Immunol. 2008 Mar 1;180(5):2863-75
pubmed: 18292508
Front Immunol. 2012 Jul 12;3:196
pubmed: 22807927
Diabetes. 2007 Jan;56(1):177-85
pubmed: 17192480
Eur J Immunol. 2008 Jul;38(7):1807-13
pubmed: 18506885
Immunity. 2015 Apr 21;42(4):607-12
pubmed: 25902480
Viruses. 2020 Jan 15;12(1):
pubmed: 31952232
Trends Endocrinol Metab. 2006 May-Jun;17(4):128-35
pubmed: 16580840
Phys Ther. 2008 Nov;88(11):1254-64
pubmed: 18801858
Nat Med. 2013 Jan;19(1):65-73
pubmed: 23242473
J Immunol. 2017 Feb 15;198(4):1512-1520
pubmed: 28087671
Immunol Rev. 2014 May;259(1):259-72
pubmed: 24712471
Sci Transl Med. 2013 Feb 20;5(173):173ra23
pubmed: 23427243
Int Immunol. 2015 Oct;27(10):471-7
pubmed: 26254185
Proc Natl Acad Sci U S A. 2019 Oct 22;116(43):21673-21684
pubmed: 31591231
Discov Med. 2016 Mar;21(115):213-9
pubmed: 27115172
Nature. 2010 Apr 29;464(7293):1293-300
pubmed: 20432533
J Immunol. 2014 Sep 1;193(5):2258-66
pubmed: 25080484
Diabetologia. 2012 Aug;55(8):2142-7
pubmed: 22638547
Immunity. 2008 May;28(5):639-50
pubmed: 18482568
BMJ. 2011 Sep 08;343:d5364
pubmed: 21903695