Pathways of heme utilization in fungi.
CFEM protein
Fungi
Heme
Hemophore
Iron acquisition
Journal
Biochimica et biophysica acta. Molecular cell research
ISSN: 1879-2596
Titre abrégé: Biochim Biophys Acta Mol Cell Res
Pays: Netherlands
ID NLM: 101731731
Informations de publication
Date de publication:
11 2020
11 2020
Historique:
received:
31
05
2020
revised:
02
08
2020
accepted:
03
08
2020
pubmed:
11
8
2020
medline:
8
1
2021
entrez:
11
8
2020
Statut:
ppublish
Résumé
Iron acquisition is challenging in most environments. As an alternative to elemental iron, organisms can take up iron-protoporphyrin IX, or heme. Heme can be found in decaying organic matter and is particularly prevalent in animal hosts. Fungi have evolved at least three distinct endocytosis-mediated heme uptake systems, which have been studied in detail in the organisms Candida albicans, Cryptococcus neoformans and Schizosaccharomyces pombe. Here we summarize the known molecular details of these three uptake systems that enable parasitic and saprophytic fungi to take advantage of external heme as either cellular iron or heme sources.
Identifiants
pubmed: 32777371
pii: S0167-4889(20)30175-0
doi: 10.1016/j.bbamcr.2020.118817
pii:
doi:
Substances chimiques
Protoporphyrins
0
Heme
42VZT0U6YR
protoporphyrin IX
C2K325S808
Iron
E1UOL152H7
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
118817Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.