Mediator subunit MED25: at the nexus of jasmonate signaling.
Journal
Current opinion in plant biology
ISSN: 1879-0356
Titre abrégé: Curr Opin Plant Biol
Pays: England
ID NLM: 100883395
Informations de publication
Date de publication:
10 2020
10 2020
Historique:
received:
06
02
2020
revised:
16
06
2020
accepted:
24
06
2020
pubmed:
11
8
2020
medline:
14
1
2021
entrez:
11
8
2020
Statut:
ppublish
Résumé
Upon perception by plant cells, the immunity hormone jasmonate (JA) triggers a genome-wide transcriptional program, which is largely regulated by the master transcription factor MYC2. The function of MYC2 depends on its physical and functional interaction with MED25, a subunit of the Mediator transcriptional co-activator complex. In addition to interacting with MYC2 and RNA polymerase II for preinitiation complex formation, MED25 also interacts with multiple genetic and epigenetic regulators and controls almost every step of MYC2-dependent transcription, including nuclear hormone receptor activation, epigenetic regulation, mRNA processing, transcriptional termination, and chromatin loop formation. These diversified functions have ascribed MED25 to a signal-processing and signal-integrating center during JA-regulated gene transcription. This review is focused on the interactions of MED25 with diverse transcriptional regulators and how these mechanistic interactions contribute to the initiation, amplification, and fine tuning of the transcriptional output of JA signaling.
Identifiants
pubmed: 32777679
pii: S1369-5266(20)30086-8
doi: 10.1016/j.pbi.2020.06.006
pii:
doi:
Substances chimiques
Arabidopsis Proteins
0
Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
0
Cyclopentanes
0
DNA-Binding Proteins
0
Oxylipins
0
jasmonic acid
6RI5N05OWW
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
78-86Informations de copyright
Copyright © 2020 The Author(s). Published by Elsevier Ltd.. All rights reserved.