Apc
5-Methylcytosine
/ analogs & derivatives
Adenomatous Polyposis Coli Protein
/ genetics
Animals
Chromatography, Liquid
Colon
/ chemistry
Female
Intestinal Neoplasms
/ genetics
Intestine, Small
/ chemistry
Male
Mass Spectrometry
Metabolomics
Mice
Mice, Inbred C57BL
Proton Magnetic Resonance Spectroscopy
Pylorus
/ chemistry
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
12 08 2020
12 08 2020
Historique:
received:
05
02
2020
accepted:
29
07
2020
entrez:
14
8
2020
pubmed:
14
8
2020
medline:
12
1
2021
Statut:
epublish
Résumé
Topographical variations of metabolite concentrations have been reported in the duodenum, jejunum and ileum of the small intestine, and in human intestinal tumours from those regions, but there are no published metabolite concentrations measurements correlated with linear position in the mouse small intestine or intestinal tumours. Since DNA methylation dynamics are influenced by metabolite concentrations, they too could show linear anatomical variation. We measured metabolites by HR-MAS
Identifiants
pubmed: 32788746
doi: 10.1038/s41598-020-70579-w
pii: 10.1038/s41598-020-70579-w
pmc: PMC7423954
doi:
Substances chimiques
Adenomatous Polyposis Coli Protein
0
adenomatous polyposis coli protein, mouse
0
5-hydroxymethylcytosine
1123-95-1
5-Methylcytosine
6R795CQT4H
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
13616Subventions
Organisme : Cancer Research UK
ID : C14303/A17197
Pays : United Kingdom
Organisme : Cancer Research UK
ID : C9545/A17197
Pays : United Kingdom
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