Natural variation at FLM splicing has pleiotropic effects modulating ecological strategies in Arabidopsis thaliana.
Alleles
Arabidopsis
/ genetics
Arabidopsis Proteins
/ genetics
Evolution, Molecular
Gene Expression Regulation, Plant
/ genetics
Genetic Pleiotropy
Genetic Variation
Introns
MADS Domain Proteins
/ genetics
Phenotype
Plant Leaves
/ genetics
Quantitative Trait Loci
/ genetics
RNA Splicing
/ genetics
Temperature
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
18 08 2020
18 08 2020
Historique:
received:
09
09
2019
accepted:
16
07
2020
entrez:
20
8
2020
pubmed:
20
8
2020
medline:
17
9
2020
Statut:
epublish
Résumé
Investigating the evolution of complex phenotypes and the underlying molecular bases of their variation is critical to understand how organisms adapt to their environment. Applying classical quantitative genetics on a segregating population derived from a Can-0xCol-0 cross, we identify the MADS-box transcription factor FLOWERING LOCUS M (FLM) as a player of the phenotypic variation in plant growth and color. We show that allelic variation at FLM modulates plant growth strategy along the leaf economics spectrum, a trade-off between resource acquisition and resource conservation, observable across thousands of plant species. Functional differences at FLM rely on a single intronic substitution, disturbing transcript splicing and leading to the accumulation of non-functional FLM transcripts. Associations between this substitution and phenotypic and climatic data across Arabidopsis natural populations, show how noncoding genetic variation at a single gene might be adaptive through pleiotropic effects.
Identifiants
pubmed: 32811829
doi: 10.1038/s41467-020-17896-w
pii: 10.1038/s41467-020-17896-w
pmc: PMC7435183
doi:
Substances chimiques
Arabidopsis Proteins
0
FLM protein, Arabidopsis
0
MADS Domain Proteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
4140Références
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