Processing of
3' Untranslated Regions
Adenosine Deaminase
/ genetics
Alu Elements
Argonaute Proteins
/ genetics
DEAD-box RNA Helicases
/ genetics
HeLa Cells
Hep G2 Cells
Humans
Nucleic Acid Conformation
RNA
/ chemistry
RNA Editing
RNA Processing, Post-Transcriptional
RNA, Small Interfering
/ chemistry
RNA-Binding Proteins
/ genetics
Ribonuclease III
/ genetics
ADAR1
Alu
DICER
RNA editing
RNAi
siRNA
Journal
RNA (New York, N.Y.)
ISSN: 1469-9001
Titre abrégé: RNA
Pays: United States
ID NLM: 9509184
Informations de publication
Date de publication:
12 2020
12 2020
Historique:
received:
10
06
2020
accepted:
12
08
2020
pubmed:
21
8
2020
medline:
26
1
2021
entrez:
21
8
2020
Statut:
ppublish
Résumé
In addition to adenosine-to-inosine RNA editing activities, ADAR1 has been shown to have various RNA editing-independent activities including modulation of RNAi efficacy. We previously reported that ADAR1 forms a heterodimer complex with DICER and facilitates processing of pre-miRNAs to mature miRNAs. In addition to miRNA synthesis, DICER is involved in processing of long dsRNAs into small RNAs (endo-siRNAs). Generation of retrotransposon-derived endo-siRNAs by DICER and their functions in regulation of transcripts in mouse oocytes has been previously reported. However, the synthesis and functions of endo-siRNAs in somatic cells remain largely unknown. Here, we report that ADAR1 together with DICER generates endogenous small RNAs,
Identifiants
pubmed: 32817447
pii: rna.076745.120
doi: 10.1261/rna.076745.120
pmc: PMC7668262
doi:
Substances chimiques
3' Untranslated Regions
0
AGO2 protein, human
0
Argonaute Proteins
0
RNA, Small Interfering
0
RNA-Binding Proteins
0
RNA
63231-63-0
DICER1 protein, human
EC 3.1.26.3
Ribonuclease III
EC 3.1.26.3
ADAR protein, human
EC 3.5.4.37
Adenosine Deaminase
EC 3.5.4.4
DEAD-box RNA Helicases
EC 3.6.4.13
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1801-1814Subventions
Organisme : NCI NIH HHS
ID : R01 CA175058
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM040536
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM130716
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA010815
Pays : United States
Organisme : NCI NIH HHS
ID : R50 CA211199
Pays : United States
Informations de copyright
© 2020 Shiromoto et al.; Published by Cold Spring Harbor Laboratory Press for the RNA Society.
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