Early precursor T cells establish and propagate T cell exhaustion in chronic infection.

Animals CD8-Positive T-Lymphocytes / immunology Cell Differentiation Cell Self Renewal Cells, Cultured Chronic Disease Clonal Anergy Epigenesis, Genetic Hepatocyte Nuclear Factor 1-alpha / metabolism Immune Tolerance Lymphocytic Choriomeningitis / immunology Lymphocytic choriomeningitis virus / physiology Mice Mice, Inbred C57BL Mice, Transgenic Precursor Cells, T-Lymphoid / immunology Receptors, Antigen, T-Cell / metabolism T-Cell Antigen Receptor Specificity

Journal

Nature immunology
ISSN: 1529-2916
Titre abrégé: Nat Immunol
Pays: United States
ID NLM: 100941354

Informations de publication

Date de publication:
10 2020
Historique:
received: 13 03 2020
accepted: 10 07 2020
pubmed: 26 8 2020
medline: 7 1 2021
entrez: 26 8 2020
Statut: ppublish

Résumé

CD8

Identifiants

DOI: 10.1038/s41590-020-0760-z PMID: 32839610
pubmed: 32839610
doi: 10.1038/s41590-020-0760-z
pii: 10.1038/s41590-020-0760-z
doi:

Substances chimiques

Hepatocyte Nuclear Factor 1-alpha 0
Hnf1a protein, mouse 0
Receptors, Antigen, T-Cell 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1256-1266

Références

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Auteurs

Daniel T Utzschneider (DT)

Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Australia. daniel.utzschneider@unimelb.edu.au.
ORCID: 0000-0003-2205-9057

Sarah S Gabriel (SS)

Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Australia.

David Chisanga (D)

Olivia Newton-John Cancer Research Institute, Heidelberg, Australia.
The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia.
Department of Medical Biology, University of Melbourne, Melbourne, Australia.
School of Cancer Medicine, La Trobe University, Heidelberg, Victoria, Australia.
ORCID: 0000-0002-0421-3957

Renee Gloury (R)

Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Australia.

Patrick M Gubser (PM)

Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Australia.

Ajithkumar Vasanthakumar (A)

Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Australia.
The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia.
ORCID: 0000-0002-1620-7781

Wei Shi (W)

Olivia Newton-John Cancer Research Institute, Heidelberg, Australia.
The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia.
School of Cancer Medicine, La Trobe University, Heidelberg, Victoria, Australia.
School of Computing and Information Systems, University of Melbourne, Melbourne, Australia.

Axel Kallies (A)

Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Australia. axel.kallies@unimelb.edu.au.
The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia. axel.kallies@unimelb.edu.au.
ORCID: 0000-0002-6312-6968

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Early precursor T cells establish and...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Lymphocytes T CD8+ › Early precursor T cells establish and...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Différenciation cellulaire › Early precursor T cells establish and...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Croissance › Processus de croissance cellulaire › Prolifération cellulaire › Division cellulaire › Auto-renouvellement cellulaire › Early precursor T cells establish and...
questionsmedicales.fr › Cellules › Cellules cultivées › Early precursor T cells establish and...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Caractéristiques de la maladie › Maladie chronique › Early precursor T cells establish and...
questionsmedicales.fr › Phénomènes du système immunitaire › Immunomodulation › Tolérance immunitaire › Anergie clonale › Early precursor T cells establish and...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Épigenèse génétique › Early precursor T cells establish and...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs nucléaires hépatocytaires › Facteur nucléaire hépatocytaire HNF-1 › Facteur nucléaire hépatocytaire HNF-1 alpha › Early precursor T cells establish and...
questionsmedicales.fr › Phénomènes du système immunitaire › Immunomodulation › Tolérance immunitaire › Early precursor T cells establish and...
questionsmedicales.fr › Maladies du système nerveux › Méningite › Méningite virale › Chorioméningite lymphocytaire › Early precursor T cells establish and...
questionsmedicales.fr › Virus › Virus à ARN › Virus à ARN de polarité négative › Arenaviridae › Arenavirus › Arénavirus de l'Ancien Monde › Virus de la chorioméningite lymphocytaire › Early precursor T cells establish and...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Early precursor T cells establish and...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Early precursor T cells establish and...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Early precursor T cells establish and...
questionsmedicales.fr › Cellules › Cellules souches › Précurseurs lymphoïdes T › Early precursor T cells establish and...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs immunologiques › Récepteurs aux antigènes › Récepteurs aux antigènes des cellules T › Early precursor T cells establish and...
questionsmedicales.fr › Phénomènes du système immunitaire › Immunité › Spécificité antigénique des récepteurs des lymphocytes T › Early precursor T cells establish and...