Reductive Charge Transfer through an RNA Aptamer.
RNA aptamers
charge transfer
fluorescence quenching
optical spectroscopy
pyrene-modified RNA
Journal
Angewandte Chemie (International ed. in English)
ISSN: 1521-3773
Titre abrégé: Angew Chem Int Ed Engl
Pays: Germany
ID NLM: 0370543
Informations de publication
Date de publication:
14 12 2020
14 12 2020
Historique:
received:
08
07
2020
revised:
20
08
2020
pubmed:
28
8
2020
medline:
23
3
2021
entrez:
28
8
2020
Statut:
ppublish
Résumé
The transfer of charges through double helical DNA is a very well investigated bioelectric phenomenon. RNA, on the contrary, has been less studied in this regard. The few available data report on charge transfer through RNA duplex structures mainly composed of homonucleotide sequences. In the light of the RNA world scenarios, it is an interesting question, if charge transfer can be coupled with RNA function. Functional RNAs however, contain versatile structural motifs. Therefore, electron transport also through non-Watson-Crick base-paired regions might be required. We here demonstrate distance-dependent reductive charge transfer through RNA duplexes and through the non-Watson-Crick base-paired region of an RNA aptamer.
Identifiants
pubmed: 32852119
doi: 10.1002/anie.202009430
pmc: PMC7756803
doi:
Substances chimiques
Aptamers, Nucleotide
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
22999-23004Informations de copyright
© 2020 The Authors. Published by Wiley-VCH GmbH.
Références
Angew Chem Int Ed Engl. 2020 Dec 14;59(51):22999-23004
pubmed: 32852119
Chem Rev. 2010 Mar 10;110(3):1642-62
pubmed: 20214403
J Mol Evol. 2016 Dec;83(5-6):169-175
pubmed: 27866234
J Am Chem Soc. 2008 Jan 30;130(4):1152-3
pubmed: 18183988
J Phys Chem B. 2015 Jun 25;119(25):7994-8000
pubmed: 26042867
Org Biomol Chem. 2018 Nov 7;16(41):7663-7673
pubmed: 30283974
Nucleic Acids Res. 1998 Jul 15;26(14):3379-84
pubmed: 9649622
Science. 1993 Nov 12;262(5136):1025-9
pubmed: 7802858
Science. 1988 Apr 22;240(4851):440-7
pubmed: 17784065
Angew Chem Int Ed Engl. 2012 Oct 1;51(40):10026-9
pubmed: 22945791
J Am Chem Soc. 2010 Oct 20;132(41):14361-3
pubmed: 20873822
Chem Sci. 2017 Mar 1;8(3):1752-1762
pubmed: 28451299
Nucleic Acids Res. 2005 Oct 19;33(18):5887-95
pubmed: 16237124
Proc Natl Acad Sci U S A. 2007 Jul 3;104(27):11179-83
pubmed: 17592151
Nucleic Acids Res. 1999 Dec 15;27(24):4830-7
pubmed: 10572185
J Mol Biol. 1996 May 10;258(3):480-500
pubmed: 8642604
Nat Prod Rep. 2006 Dec;23(6):973-1006
pubmed: 17119642
Chemphyschem. 2015 Jun 8;16(8):1607-12
pubmed: 25784385
Angew Chem Int Ed Engl. 2016 Jul 18;55(30):8715-7
pubmed: 27243800
J Am Chem Soc. 2009 Sep 23;131(37):13188-9
pubmed: 19754178
Nat Chem. 2011 Mar;3(3):228-33
pubmed: 21336329
Angew Chem Int Ed Engl. 2006 Mar 20;45(13):2127-9
pubmed: 16502442
RNA. 2005 Oct;11(10):1514-20
pubmed: 16199761
Bioorg Med Chem. 2011 Nov 15;19(22):6881-4
pubmed: 22014752