COVID-19 and Genetic Variants of Protein Involved in the SARS-CoV-2 Entry into the Host Cells.
Adolescent
Adult
Aged
Aged, 80 and over
Basigin
/ genetics
COVID-19
Child
Child, Preschool
Coronavirus Infections
/ genetics
Dipeptidyl Peptidase 4
/ genetics
Exome
Female
Furin
/ genetics
Humans
Male
Middle Aged
Mutation
Pandemics
Pneumonia, Viral
/ genetics
Polymorphism, Single Nucleotide
Serine Endopeptidases
/ genetics
COVID-19
PCSK3
SARS-CoV-2
TMPRSS2
genetic variants
host genetic variability
Journal
Genes
ISSN: 2073-4425
Titre abrégé: Genes (Basel)
Pays: Switzerland
ID NLM: 101551097
Informations de publication
Date de publication:
27 08 2020
27 08 2020
Historique:
received:
13
07
2020
revised:
22
08
2020
accepted:
26
08
2020
entrez:
2
9
2020
pubmed:
2
9
2020
medline:
12
9
2020
Statut:
epublish
Résumé
The recent global COVID-19 public health emergency is caused by SARS-CoV-2 infections and can manifest extremely variable clinical symptoms. Host human genetic variability could influence susceptibility and response to infection. It is known that ACE2 acts as a receptor for this pathogen, but the viral entry into the target cell also depends on other proteins. The aim of this study was to investigate the variability of genes coding for these proteins involved in the SARS-CoV-2 entry into the cells. We analyzed 131 COVID-19 patients by exome sequencing and examined the genetic variants of
Identifiants
pubmed: 32867305
pii: genes11091010
doi: 10.3390/genes11091010
pmc: PMC7565048
pii:
doi:
Substances chimiques
BSG protein, human
0
Basigin
136894-56-9
DPP4 protein, human
EC 3.4.14.5
Dipeptidyl Peptidase 4
EC 3.4.14.5
Serine Endopeptidases
EC 3.4.21.-
TMPRSS2 protein, human
EC 3.4.21.-
FURIN protein, human
EC 3.4.21.75
Furin
EC 3.4.21.75
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Rotary Club "Sibaris" Italy
ID : 2020
Pays : International
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