The ESCRT-III complex is required for nuclear pore complex sequestration and regulates gamete replicative lifespan in budding yeast meiosis.
ESCRT-III
cellular aging
lem-domain protein
meiosis
nuclear envelope
nuclear pore complex
replicative lifespan
Journal
Nucleus (Austin, Tex.)
ISSN: 1949-1042
Titre abrégé: Nucleus
Pays: United States
ID NLM: 101518322
Informations de publication
Date de publication:
12 2020
12 2020
Historique:
entrez:
7
9
2020
pubmed:
8
9
2020
medline:
3
6
2021
Statut:
ppublish
Résumé
Cellular aging occurs as a cell loses its ability to maintain homeostasis. Aging cells eliminate damaged cellular compartments and other senescence factors via self-renewal. The mechanism that regulates cellular rejuvenation remains to be further elucidated. Using budding yeast gametogenesis as a model, we show here that the endosomal sorting complex required for transport (ESCRT) III regulates nuclear envelope organization. During gametogenesis, the nuclear pore complex (NPC) and other senescence factors are sequestered away from the prospore nuclei. We show that the LEM-domain protein Heh1 (Src1) facilitates the nuclear recruitment of ESCRT-III, which is required for meiotic NPC sequestration and nuclear envelope remodeling. Furthermore, ESCRT-III-mediated nuclear reorganization appears to be critical for gamete rejuvenation, as hindering this process curtails either directly or indirectly the replicative lifespan in gametes. Our findings demonstrate the importance of ESCRT-III in nuclear envelope remodeling and its potential role in eliminating senescence factors during gametogenesis.
Identifiants
pubmed: 32893723
doi: 10.1080/19491034.2020.1812872
pmc: PMC7529410
doi:
Substances chimiques
Endosomal Sorting Complexes Required for Transport
0
Membrane Proteins
0
Saccharomyces cerevisiae Proteins
0
Src1 protein, S cerevisiae
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Video-Audio Media
Langues
eng
Sous-ensembles de citation
IM
Pagination
219-236Subventions
Organisme : NIGMS NIH HHS
ID : R01 GM117102
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM138838
Pays : United States
Organisme : NHLBI NIH HHS
ID : T32 HL007843
Pays : United States
Organisme : National Science Foundation
ID : MCB1951313
Pays : International
Références
Curr Genet. 2020 Jun;66(3):487-493
pubmed: 31915924
Nat Commun. 2017 Oct 24;8(1):1107
pubmed: 29062044
J Cell Biol. 2016 Oct 10;215(1):57-76
pubmed: 27697925
Nature. 2001 Nov 1;414(6859):105-11
pubmed: 11689955
Mol Biol Cell. 2015 Apr 1;26(7):1386-94
pubmed: 25631821
Annu Rev Microbiol. 1998;52:533-60
pubmed: 9891807
Cell. 2009 Jan 23;136(2):284-95
pubmed: 19167330
PLoS Genet. 2017 Jun 13;13(6):e1006830
pubmed: 28609436
Nature. 2010 Mar 25;464(7288):513-9
pubmed: 20336133
EMBO J. 2016 Nov 15;35(22):2447-2467
pubmed: 27733427
Yeast. 1998 Jul;14(10):953-61
pubmed: 9717241
Dev Cell. 2009 Jun;16(6):844-55
pubmed: 19531355
EMBO J. 2000 Jul 17;19(14):3657-67
pubmed: 10899120
Genetics. 2011 Nov;189(3):737-65
pubmed: 22084423
Genetics. 2012 Mar;190(3):855-83
pubmed: 22419078
Curr Biol. 2010 Nov 9;20(21):1913-8
pubmed: 20970334
Mol Biol Cell. 2014 Oct 1;25(19):2934-47
pubmed: 25103240
Cell. 2008 Apr 18;133(2):280-91
pubmed: 18423199
Nature. 2015 Jun 11;522(7555):236-9
pubmed: 26040713
J Bacteriol. 1989 Jan;171(1):37-42
pubmed: 2644196
Cell. 1997 Dec 26;91(7):1033-42
pubmed: 9428525
J Cell Biol. 2013 Oct 28;203(2):215-32
pubmed: 24165936
J Cell Biol. 2009 Sep 7;186(5):713-25
pubmed: 19736318
Nature. 1959 Jun 20;183(4677):1751-2
pubmed: 13666896
J Cell Biol. 1994 Dec;127(6 Pt 2):1985-93
pubmed: 7806576
Science. 2011 Jun 24;332(6037):1554-7
pubmed: 21700873
Science. 1998 Oct 23;282(5389):699-705
pubmed: 9784122
J Cell Biol. 2001 Sep 3;154(5):937-50
pubmed: 11535617
J Cell Biol. 2013 Oct 28;203(2):187-96
pubmed: 24165935
Semin Cell Dev Biol. 2018 Feb;74:50-65
pubmed: 28843980
Elife. 2019 Apr 03;8:
pubmed: 30942170
J Cell Biol. 2000 Feb 21;148(4):635-51
pubmed: 10684247
Elife. 2019 Aug 09;8:
pubmed: 31397671
Genetics. 2006 Mar;172(3):1441-57
pubmed: 16361228
Cell Metab. 2012 Jul 3;16(1):18-31
pubmed: 22768836
Elife. 2016 Sep 15;5:
pubmed: 27630123
Science. 2003 Mar 14;299(5613):1751-3
pubmed: 12610228
Nat Rev Mol Cell Biol. 2017 Feb;18(2):73-89
pubmed: 27999437
J Cell Biol. 1998 Jan 12;140(1):29-37
pubmed: 9425151
Cold Spring Harb Symp Quant Biol. 2011;76:73-80
pubmed: 21890640
Annu Rev Cell Dev Biol. 2018 Oct 6;34:85-109
pubmed: 30095293
Cell. 2014 Oct 9;159(2):388-401
pubmed: 25303532
J Cell Biol. 2014 Apr 28;205(2):133-41
pubmed: 24751535
Trends Biochem Sci. 2016 Jan;41(1):46-61
pubmed: 26705895
Chromosome Res. 2004;12(5):427-38
pubmed: 15252239
Nature. 2020 Jun;582(7810):115-118
pubmed: 32494070
Mol Cell Biol. 2011 Aug;31(16):3378-95
pubmed: 21670151
Nature. 2018 Mar 22;555(7697):475-482
pubmed: 29539637
J Cell Biol. 2001 Jun 25;153(7):1465-78
pubmed: 11425876
Cell Rep. 2012 Oct 25;2(4):738-47
pubmed: 23022486
Nat Rev Mol Cell Biol. 2017 Apr;18(4):229-245
pubmed: 28120913
Nature. 2015 Jun 11;522(7555):231-5
pubmed: 26040712
Curr Biol. 2010 Nov 9;20(21):1919-25
pubmed: 20970342