The indirect γ-aminobutyric acid (GABA) receptor agonist gabaculine-induced loss of the righting reflex may inhibit the descending analgesic pathway.

Adrenergic alpha-2 Receptor Agonists / pharmacology Analgesics / metabolism Animals Baclofen / pharmacology Cyclohexanecarboxylic Acids / pharmacology Dexmedetomidine / pharmacology GABA Agonists / pharmacology Ganglia, Spinal / drug effects Male Mice Morphine / pharmacology Muscimol / pharmacology Neural Pathways / drug effects Neurons / drug effects Pain Measurement / drug effects Rats Reflex, Righting / drug effects Signal Transduction / drug effects Spinal Cord / drug effects Substance P / drug effects
Descending analgesic pathway Dexmedetomidine GABA receptor agonists Immobility Morphine Substance P

Journal

Pharmacology, biochemistry, and behavior
ISSN: 1873-5177
Titre abrégé: Pharmacol Biochem Behav
Pays: United States
ID NLM: 0367050

Informations de publication

Date de publication:
11 2020
Historique:
received: 28 03 2020
revised: 27 05 2020
accepted: 02 09 2020
pubmed: 11 9 2020
medline: 14 4 2021
entrez: 10 9 2020
Statut: ppublish

Résumé

In the spinal cord, γ-aminobutyric acid (GABA) interneurons play an essential role in antinociception. However, not all actions of GABA favor antinociception at the supraspinal level. We previously reported that gabaculine, which increases endogenous GABA in the synaptic clefts, induces loss of the righting reflex (LORR) that is one indicator of hypnosis, but not immobility in response to noxious stimulus. A slow pain is transmitted to the spinal cord via C fibers and evokes substance P (SP) release from their terminals. However, the antinociceptive effects of gabaculine are still unknown. Our study examined whether the analgesic effects of the opioid morphine or the α

Identifiants

DOI: 10.1016/j.pbb.2020.173034 PMID: 32910929
pubmed: 32910929
pii: S0091-3057(20)30191-X
doi: 10.1016/j.pbb.2020.173034
pii:
doi:

Substances chimiques

Adrenergic alpha-2 Receptor Agonists 0
Analgesics 0
Cyclohexanecarboxylic Acids 0
GABA Agonists 0
Muscimol 2763-96-4
Substance P 33507-63-0
gabaculine 3F3ENU341O
Dexmedetomidine 67VB76HONO
Morphine 76I7G6D29C
Baclofen H789N3FKE8

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

173034

Informations de copyright

Copyright © 2020 Elsevier Inc. All rights reserved.

Auteurs

Yuya Ogawa (Y)

Section of Dental Anesthesiology, Department of Oral & Maxillofacial Surgery and Oral Medicine, Hiroshima University Hospital, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551, Japan.

Masahiro Irifune (M)

Department of Dental Anesthesiology, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553, Japan. Electronic address: mirifun@hiroshima-u.ac.jp.

Akari Mukai (A)

Department of Dental Anesthesiology, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553, Japan.

Yoshitaka Shimizu (Y)

Department of Dental Anesthesiology, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553, Japan.

Mitsuru Doi (M)

Department of Dental Anesthesiology, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553, Japan.

Kana Oue (K)

Section of Dental Anesthesiology, Department of Oral & Maxillofacial Surgery and Oral Medicine, Hiroshima University Hospital, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551, Japan.

Mitsuhiro Yoshida (M)

Section of Dental Anesthesiology, Department of Oral & Maxillofacial Surgery and Oral Medicine, Hiroshima University Hospital, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551, Japan.

Takashi Kanematsu (T)

Department of Cellular and Molecular Pharmacology, Graduate School of Biomedical and Health Sciences, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553, Japan.

Norimitsu Morioka (N)

Department of Pharmacology, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553, Japan.

Yoshihiro Nakata (Y)

Department of Pharmacology, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553, Japan.

Norio Sakai (N)

Department of Molecular and Pharmacological Neuroscience, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553, Japan.

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Agents neuromédiateurs › Agents adrénergiques › Agonistes adrénergiques › Agonistes alpha-adrénergiques › Agonistes des récepteurs alpha-2 adrénergiques › The indirect γ-aminobutyric acid (GABA)...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents du système nerveux central › Analgésiques › The indirect γ-aminobutyric acid (GABA)...
questionsmedicales.fr › Eucaryotes › Animaux › The indirect γ-aminobutyric acid (GABA)...
questionsmedicales.fr › Composés chimiques organiques › Acides carboxyliques › Acides acycliques › Baclofène › The indirect γ-aminobutyric acid (GABA)...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures cycliques › Hydrocarbures alicycliques › Cyclohexanes › Acides cyclohexanecarboxyliques › The indirect γ-aminobutyric acid (GABA)...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Azoles › Imidazoles › Dexmédétomidine › The indirect γ-aminobutyric acid (GABA)...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Agents neuromédiateurs › Agents GABA › Agonistes GABA › The indirect γ-aminobutyric acid (GABA)...
questionsmedicales.fr › Système nerveux › Système nerveux périphérique › Nerfs périphériques › Nerfs spinaux › Racines des nerfs spinaux › Ganglions sensitifs des nerfs spinaux › The indirect γ-aminobutyric acid (GABA)...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › The indirect γ-aminobutyric acid (GABA)...
questionsmedicales.fr › Composés polycycliques › Hydrocarbures aromatiques polycycliques › Phénanthrènes › Morphinanes › Dérivés de la morphine › Morphine › The indirect γ-aminobutyric acid (GABA)...
questionsmedicales.fr › Facteurs biologiques › Toxines biologiques › Mycotoxines › Muscimol › The indirect γ-aminobutyric acid (GABA)...
questionsmedicales.fr › Système nerveux › Voies nerveuses › The indirect γ-aminobutyric acid (GABA)...
questionsmedicales.fr › Cellules › Neurones › The indirect γ-aminobutyric acid (GABA)...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Examen physique › Examen neurologique › Mesure de la douleur › The indirect γ-aminobutyric acid (GABA)...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › The indirect γ-aminobutyric acid (GABA)...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Réflexe › Réflexe de redressement › The indirect γ-aminobutyric acid (GABA)...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › The indirect γ-aminobutyric acid (GABA)...
questionsmedicales.fr › Système nerveux › Système nerveux central › Moelle spinale › The indirect γ-aminobutyric acid (GABA)...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Kinines › Tachykinines › Substance P › The indirect γ-aminobutyric acid (GABA)...