Adenosine A2a Receptor Stimulation Attenuates Ischemia-Reperfusion Injury and Improves Survival in A Porcine Model of DCD Liver Transplantation.
Adenosine
/ analogs & derivatives
Adenosine A2 Receptor Agonists
/ pharmacology
Animals
Disease Models, Animal
Female
Glucose
/ pharmacology
Liver
/ drug effects
Liver Transplantation
/ mortality
Living Donors
Mannitol
/ pharmacology
Organ Preservation
/ methods
Organ Preservation Solutions
/ pharmacology
Phenethylamines
/ pharmacology
Potassium Chloride
/ pharmacology
Procaine
/ pharmacology
Receptor, Adenosine A2A
/ metabolism
Reperfusion Injury
/ drug therapy
Swine
Warm Ischemia
/ methods
adenosine A2a agonist
donation after circulatory death
hepatoprotection
liver transplantation
microcirculation
porcine model
reperfusion injury
survival
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
14 Sep 2020
14 Sep 2020
Historique:
received:
02
08
2020
revised:
08
09
2020
accepted:
11
09
2020
entrez:
17
9
2020
pubmed:
18
9
2020
medline:
25
2
2021
Statut:
epublish
Résumé
Orthotopic liver transplantation (OLT) using allografts from donation after circulatory death (DCD) is potentially associated with compromised clinical outcomes due to ischemia-reperfusion injury (IRI)-induced organ damage and graft-related complications. The aim of this study was to provide in vivo data on the effects of adenosine A
Identifiants
pubmed: 32938013
pii: ijms21186747
doi: 10.3390/ijms21186747
pmc: PMC7555737
pii:
doi:
Substances chimiques
Adenosine A2 Receptor Agonists
0
Bretschneider cardioplegic solution
0
Organ Preservation Solutions
0
Phenethylamines
0
Receptor, Adenosine A2A
0
2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine
120225-54-9
Mannitol
3OWL53L36A
Procaine
4Z8Y51M438
Potassium Chloride
660YQ98I10
Glucose
IY9XDZ35W2
Adenosine
K72T3FS567
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : START Program Faculty of Medicine, RWTH Aachen University
ID : #23/19
Organisme : B.Braun Foundation, Melsungen, Germany
ID : BBST-S-17-00240
Organisme : Clinician Scientist Program Faculty of Medicine, RWTH Aachen University
ID : n.a.
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