Characterization of the intergenerational impact of in utero and postnatal oxycodone exposure.
Journal
Translational psychiatry
ISSN: 2158-3188
Titre abrégé: Transl Psychiatry
Pays: United States
ID NLM: 101562664
Informations de publication
Date de publication:
23 09 2020
23 09 2020
Historique:
received:
26
08
2020
accepted:
10
09
2020
revised:
09
09
2020
entrez:
24
9
2020
pubmed:
25
9
2020
medline:
22
6
2021
Statut:
epublish
Résumé
Prescription opioid abuse during and after pregnancy is a rising public health concern. While earlier studies have documented that offspring exposed to opioids in utero have impaired neurodevelopment, a significant knowledge gap remains in comparing the overall development between offspring exposed in utero and postnatally. Adding a layer of complexity is the role of heredity in the overall development of these exposed offspring. To fill in these important knowledge gaps, the current study uses a preclinical rat model mimicking oxycodone (oxy) exposure in utero (IUO) and postnatally (PNO) to investigate comparative and intergenerational effects in the two different treatment groups. While significant phenotypic attributes were observed with the two treatments and across the two generations, RNA sequencing revealed alterations in the expression of key synaptic genes in the two exposed groups in both generations. RNA sequencing and post validation of genes using RT-PCR highlighted the differential expression of several neuropeptides associated with the hypocretin system, a system recently implicated in addiction. Further, behavior studies revealed anxiety-like behaviors and social deficits that persisted even in the subsequent generations in the two treatment groups. To summarize, our study for the first time reveals a new line of investigation on the potential risks associated with oxy use during and after pregnancy, specifically the disruption of neurodevelopment and intergenerational impact on behavior.
Identifiants
pubmed: 32968044
doi: 10.1038/s41398-020-01012-z
pii: 10.1038/s41398-020-01012-z
pmc: PMC7511347
doi:
Substances chimiques
Analgesics, Opioid
0
Oxycodone
CD35PMG570
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
329Subventions
Organisme : NIGMS NIH HHS
ID : P20 GM103427
Pays : United States
Organisme : U.S. Department of Health & Human Services | NIH | National Institute on Drug Abuse (NIDA)
ID : DA049577
Pays : International
Organisme : NIDA NIH HHS
ID : R01 DA042379
Pays : United States
Organisme : NINDS NIH HHS
ID : T32 NS105594
Pays : United States
Organisme : NIDA NIH HHS
ID : R21 DA046284
Pays : United States
Organisme : U.S. Department of Health & Human Services | NIH | National Institute on Drug Abuse (NIDA)
ID : DA046855
Pays : International
Organisme : U.S. Department of Health & Human Services | NIH | National Institute on Drug Abuse (NIDA)
ID : DA042379
Pays : International
Organisme : NIMH NIH HHS
ID : P30 MH062261
Pays : United States
Organisme : U.S. Department of Health & Human Services | NIH | National Institute on Drug Abuse (NIDA)
ID : DA046852
Pays : International
Organisme : NIDA NIH HHS
ID : R01 DA046852
Pays : United States
Organisme : U.S. Department of Health & Human Services | NIH | National Institute on Drug Abuse (NIDA)
ID : DA046284
Pays : International
Organisme : NIDA NIH HHS
ID : R21 DA049577
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA036727
Pays : United States
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