Novel phenoxy-(trifluoromethyl)pyridine-2-pyrrolidinone-based inhibitors of protoporphyrinogen oxidase: Design, synthesis, and herbicidal activity.

Chlorophyll A Enzyme Inhibitors / pharmacology Herbicides / pharmacology Molecular Docking Simulation Protoporphyrinogen Oxidase Pyridines / pharmacology Pyrrolidinones Structure-Activity Relationship
Herbicidal activity Herbicide Molecular docking PPO Phenoxypyridine-2-pyrrolidinone

Journal

Pesticide biochemistry and physiology
ISSN: 1095-9939
Titre abrégé: Pestic Biochem Physiol
Pays: United States
ID NLM: 1301573

Informations de publication

Date de publication:
Nov 2020
Historique:
received: 29 06 2020
revised: 15 08 2020
accepted: 17 08 2020
entrez: 27 9 2020
pubmed: 28 9 2020
medline: 30 9 2020
Statut: ppublish

Résumé

As important chemical pesticides, protoporphyrinogen oxidase (PPO, EC 1.3.3.4) herbicides play a vital role in weed management. Herein, in a search for novel PPO herbicides, a series of phenoxypyridine-2-pyrrolidinone derivatives were synthesized and their herbicidal activities were tested. To confirm the structures of the newly synthesized compounds, a colorless single crystal of compound 9d was obtained and crystallographic data collected. PPO inhibition experiments showed that most compounds have PPO inhibitory effects. The half-maximal inhibitory concentration (IC

Identifiants

DOI: 10.1016/j.pestbp.2020.104684 PMID: 32980064
pubmed: 32980064
pii: S0048-3575(20)30179-6
doi: 10.1016/j.pestbp.2020.104684
pii:
doi:

Substances chimiques

Enzyme Inhibitors 0
Herbicides 0
Pyridines 0
Pyrrolidinones 0
Protoporphyrinogen Oxidase EC 1.3.3.4
2-pyrrolidone KKL5D39EOL
Chlorophyll A YF5Q9EJC8Y

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

104684

Informations de copyright

Copyright © 2020 Elsevier Inc. All rights reserved.

Auteurs

Li-Xia Zhao (LX)

Department of Applied Chemistry, College of Arts and Sciences, Northeast Agricultural University, Harbin 150030, China.

Jia-Jun Hu (JJ)

Department of Applied Chemistry, College of Arts and Sciences, Northeast Agricultural University, Harbin 150030, China.

Zhi-Xin Wang (ZX)

Department of Applied Chemistry, College of Arts and Sciences, Northeast Agricultural University, Harbin 150030, China.

Min-Lei Yin (ML)

Department of Applied Chemistry, College of Arts and Sciences, Northeast Agricultural University, Harbin 150030, China.

Yue-Li Zou (YL)

Department of Applied Chemistry, College of Arts and Sciences, Northeast Agricultural University, Harbin 150030, China.

Shuang Gao (S)

Department of Applied Chemistry, College of Arts and Sciences, Northeast Agricultural University, Harbin 150030, China.

Ying Fu (Y)

Department of Applied Chemistry, College of Arts and Sciences, Northeast Agricultural University, Harbin 150030, China. Electronic address: fuying@neau.edu.cn.

Fei Ye (F)

Department of Applied Chemistry, College of Arts and Sciences, Northeast Agricultural University, Harbin 150030, China. Electronic address: yefei@neau.edu.cn.

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Classifications MeSH

questionsmedicales.fr › Composés polycycliques › Composés macrocycliques › Tétrapyrroles › Chlorophylle › Chlorophylle A › Novel...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Mécanismes moléculaires de l'action pharmacologique › Antienzymes › Novel...
questionsmedicales.fr › Actions chimiques et utilisations › Actions toxiques › Pesticides › Herbicides › Novel...
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Simulation numérique › Simulation de docking moléculaire › Novel...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protoporphyrinogen oxidase › Novel...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pyridines › Novel...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pyrrolidines › Pyrrolidones › Novel...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Relation structure-activité › Novel...