Functional CRISPR dissection of gene networks controlling human regulatory T cell identity.

Biomarkers CRISPR-Cas Systems Clustered Regularly Interspaced Short Palindromic Repeats Disease Susceptibility Gene Expression Profiling Gene Expression Regulation Gene Knockout Techniques Gene Regulatory Networks Gene Targeting Graft vs Host Disease / etiology High-Throughput Nucleotide Sequencing Humans T-Lymphocytes, Regulatory / immunology Transcriptome

Journal

Nature immunology
ISSN: 1529-2916
Titre abrégé: Nat Immunol
Pays: United States
ID NLM: 100941354

Informations de publication

Date de publication:
11 2020
Historique:
received: 08 10 2019
accepted: 12 08 2020
pubmed: 30 9 2020
medline: 26 1 2021
entrez: 29 9 2020
Statut: ppublish

Résumé

Human regulatory T (T

Identifiants

DOI: 10.1038/s41590-020-0784-4 PMID: 32989329 PMC: PMC7577958
pubmed: 32989329
doi: 10.1038/s41590-020-0784-4
pii: 10.1038/s41590-020-0784-4
pmc: PMC7577958
mid: NIHMS1620080
doi:

Substances chimiques

Biomarkers 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1456-1466

Subventions

Organisme : NIAID NIH HHS
ID : T32 AI007334
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM007618
Pays : United States
Organisme : NIAMS NIH HHS
ID : P30 AR070155
Pays : United States
Organisme : NIGMS NIH HHS
ID : P50 GM082250
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK063720
Pays : United States
Organisme : NIDDK NIH HHS
ID : DP3 DK111914
Pays : United States
Organisme : NIAID NIH HHS
ID : L40 AI140341
Pays : United States
Organisme : NIH HHS
ID : DP5 OD023056
Pays : United States

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Auteurs

Kathrin Schumann (K)

Institute for Medical Microbiology, Immunology and Hygiene, Technische Universität München (TUM), Munich, Germany. kathrin.schumann@tum.de.
Institute for Advanced Study, TUM, Munich, Germany. kathrin.schumann@tum.de.
ORCID: 0000-0002-0993-3910

Siddharth S Raju (SS)

Department of Epidemiology and Biostatistics and Institute for Human Genetics, University of California, San Francisco, CA, USA.
Department of Microbiology and Immunology, University of California, San Francisco, CA, USA.
Department of Otolaryngology-Head and Neck Surgery, University of California, San Francisco, CA, USA.
Broad Institute, Cambridge, MA, USA.
ORCID: 0000-0002-3916-0293

Michael Lauber (M)

Institute for Medical Microbiology, Immunology and Hygiene, Technische Universität München (TUM), Munich, Germany.
Institute for Advanced Study, TUM, Munich, Germany.

Saskia Kolb (S)

Institute for Medical Microbiology, Immunology and Hygiene, Technische Universität München (TUM), Munich, Germany.
Institute for Advanced Study, TUM, Munich, Germany.

Eric Shifrut (E)

Department of Microbiology and Immunology, University of California, San Francisco, CA, USA.
Diabetes Center, University of California, San Francisco, CA, USA.
Innovative Genomics Institute, University of California, Berkeley, CA, USA.
ORCID: 0000-0001-6827-0128

Jessica T Cortez (JT)

Department of Microbiology and Immunology, University of California, San Francisco, CA, USA.
Diabetes Center, University of California, San Francisco, CA, USA.
Innovative Genomics Institute, University of California, Berkeley, CA, USA.

Nikolaos Skartsis (N)

Department of Medicine, University of California, San Francisco, CA, USA.

Vinh Q Nguyen (VQ)

Department of Surgery, University of California, San Francisco, CA, USA.

Jonathan M Woo (JM)

Department of Microbiology and Immunology, University of California, San Francisco, CA, USA.
Diabetes Center, University of California, San Francisco, CA, USA.
Innovative Genomics Institute, University of California, Berkeley, CA, USA.

Theodore L Roth (TL)

Department of Microbiology and Immunology, University of California, San Francisco, CA, USA.
Diabetes Center, University of California, San Francisco, CA, USA.
Innovative Genomics Institute, University of California, Berkeley, CA, USA.
ORCID: 0000-0002-3970-9573

Ruby Yu (R)

Department of Microbiology and Immunology, University of California, San Francisco, CA, USA.
Diabetes Center, University of California, San Francisco, CA, USA.
Innovative Genomics Institute, University of California, Berkeley, CA, USA.

Michelle L T Nguyen (MLT)

Department of Microbiology and Immunology, University of California, San Francisco, CA, USA.
Diabetes Center, University of California, San Francisco, CA, USA.
Innovative Genomics Institute, University of California, Berkeley, CA, USA.

Dimitre R Simeonov (DR)

Department of Microbiology and Immunology, University of California, San Francisco, CA, USA.
Diabetes Center, University of California, San Francisco, CA, USA.
Innovative Genomics Institute, University of California, Berkeley, CA, USA.

David N Nguyen (DN)

Department of Microbiology and Immunology, University of California, San Francisco, CA, USA.
Diabetes Center, University of California, San Francisco, CA, USA.
Innovative Genomics Institute, University of California, Berkeley, CA, USA.
Department of Medicine, University of California, San Francisco, CA, USA.
ORCID: 0000-0001-6808-2717

Sasha Targ (S)

Department of Epidemiology and Biostatistics and Institute for Human Genetics, University of California, San Francisco, CA, USA.

Rachel E Gate (RE)

Department of Epidemiology and Biostatistics and Institute for Human Genetics, University of California, San Francisco, CA, USA.

Qizhi Tang (Q)

Diabetes Center, University of California, San Francisco, CA, USA.
Department of Surgery, University of California, San Francisco, CA, USA.
ORCID: 0000-0001-7313-3574

Jeffrey A Bluestone (JA)

Department of Microbiology and Immunology, University of California, San Francisco, CA, USA.
Diabetes Center, University of California, San Francisco, CA, USA.
Parker Institute for Cancer Immunotherapy, San Francisco, CA, USA.
ORCID: 0000-0001-8793-7848

Matthew H Spitzer (MH)

Department of Microbiology and Immunology, University of California, San Francisco, CA, USA.
Department of Otolaryngology-Head and Neck Surgery, University of California, San Francisco, CA, USA.
Parker Institute for Cancer Immunotherapy, San Francisco, CA, USA.
Chan Zuckerberg Biohub, San Francisco, CA, USA.
Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA, USA.
ORCID: 0000-0002-5291-3819

Chun Jimmie Ye (CJ)

Department of Epidemiology and Biostatistics and Institute for Human Genetics, University of California, San Francisco, CA, USA.
Department of Medicine, University of California, San Francisco, CA, USA.
Parker Institute for Cancer Immunotherapy, San Francisco, CA, USA.
Chan Zuckerberg Biohub, San Francisco, CA, USA.
ORCID: 0000-0001-6560-3783

Alexander Marson (A)

Department of Microbiology and Immunology, University of California, San Francisco, CA, USA. alexander.marson@ucsf.edu.
Diabetes Center, University of California, San Francisco, CA, USA. alexander.marson@ucsf.edu.
Innovative Genomics Institute, University of California, Berkeley, CA, USA. alexander.marson@ucsf.edu.
Department of Medicine, University of California, San Francisco, CA, USA. alexander.marson@ucsf.edu.
Parker Institute for Cancer Immunotherapy, San Francisco, CA, USA. alexander.marson@ucsf.edu.
Chan Zuckerberg Biohub, San Francisco, CA, USA. alexander.marson@ucsf.edu.
Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA, USA. alexander.marson@ucsf.edu.
Gladstone Institutes, San Francisco, CA, USA. alexander.marson@ucsf.edu.
ORCID: 0000-0002-2734-5776

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Classifications MeSH

questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Functional CRISPR dissection of gene networks...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Épigenèse génétique › Extinction de l'expression des gènes › Systèmes CRISPR-Cas › Functional CRISPR dissection of gene networks...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Séquences répétées en tandem › Clustered regularly interspaced short palindromic repeats › Functional CRISPR dissection of gene networks...
questionsmedicales.fr › Phénomènes physiologiques › Constitution physique › Prédisposition aux maladies › Functional CRISPR dissection of gene networks...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Analyse de profil d'expression de gènes › Functional CRISPR dissection of gene networks...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Functional CRISPR dissection of gene networks...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Ciblage de gène › Techniques de knock-out de gènes › Functional CRISPR dissection of gene networks...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Séquences d'acides nucléiques régulatrices › Réseaux de régulation génique › Functional CRISPR dissection of gene networks...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Ciblage de gène › Functional CRISPR dissection of gene networks...
questionsmedicales.fr › Maladies du système immunitaire › Maladie du greffon contre l'hôte › Functional CRISPR dissection of gene networks...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Analyse de séquence › Séquençage nucléotidique à haut débit › Functional CRISPR dissection of gene networks...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Functional CRISPR dissection of gene networks...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Sous-populations de lymphocytes T › Lymphocytes T régulateurs › Functional CRISPR dissection of gene networks...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Transcriptome › Functional CRISPR dissection of gene networks...