Genome expansion in early eukaryotes drove the transition from lateral gene transfer to meiotic sex.
Muller's ratchet
deleterious mutation
evolutionary biology
genome size
lateral gene transfer
meiotic sex
none
sexual reproduction
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
29 09 2020
29 09 2020
Historique:
received:
13
05
2020
accepted:
03
09
2020
entrez:
29
9
2020
pubmed:
30
9
2020
medline:
18
3
2021
Statut:
epublish
Résumé
Prokaryotes acquire genes from the environment via lateral gene transfer (LGT). Recombination of environmental DNA can prevent the accumulation of deleterious mutations, but LGT was abandoned by the first eukaryotes in favour of sexual reproduction. Here we develop a theoretical model of a haploid population undergoing LGT which includes two new parameters, genome size and recombination length, neglected by previous theoretical models. The greater complexity of eukaryotes is linked with larger genomes and we demonstrate that the benefit of LGT declines rapidly with genome size. The degeneration of larger genomes can only be resisted by increases in recombination length, to the same order as genome size - as occurs in meiosis. Our results can explain the strong selective pressure towards the evolution of sexual cell fusion and reciprocal recombination during early eukaryotic evolution - the origin of meiotic sex.
Identifiants
pubmed: 32990598
doi: 10.7554/eLife.58873
pii: 58873
pmc: PMC7524546
doi:
pii:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Engineering and Physical Sciences Research Council
ID : EP/F500351/1
Pays : International
Organisme : Engineering and Physical Sciences Research Council
ID : EP/I017909/1
Pays : International
Organisme : Natural Environment Research Council
ID : NE/R010579/1
Pays : International
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/S003681/1
Pays : United Kingdom
Informations de copyright
© 2020, Colnaghi et al.
Déclaration de conflit d'intérêts
MC, NL, AP No competing interests declared
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