Synthetic, Mechanistic, and Biological Interrogation of

Bromides / chemistry Cyclopentanes / chemical synthesis Furans / chemical synthesis GABA-A Receptor Antagonists / chemical synthesis Ginkgo biloba / chemistry Ginkgolides / chemical synthesis Isotope Labeling Lactones / chemistry Molecular Conformation Oxidation-Reduction Stereoisomerism

Journal

Journal of the American Chemical Society
ISSN: 1520-5126
Titre abrégé: J Am Chem Soc
Pays: United States
ID NLM: 7503056

Informations de publication

Date de publication:
28 10 2020
Historique:
pubmed: 30 9 2020
medline: 16 4 2021
entrez: 29 9 2020
Statut: ppublish

Résumé

Here we interrogate the structurally dense (1.64 mcbits/Å

Identifiants

DOI: 10.1021/jacs.0c08231 PMID: 32991152 PMC: PMC7727090
pubmed: 32991152
doi: 10.1021/jacs.0c08231
pmc: PMC7727090
mid: NIHMS1633652
doi:

Substances chimiques

Bromides 0
Cyclopentanes 0
Furans 0
GABA-A Receptor Antagonists 0
Ginkgolides 0
Lactones 0
bilobalide M81D2O8H7U

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

18599-18618

Subventions

Organisme : NIAAA NIH HHS
ID : P60 AA006420
Pays : United States
Organisme : NIAAA NIH HHS
ID : R01 AA015566
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM122606
Pays : United States

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Auteurs

Robert M Demoret (RM)

Department of Chemistry, Scripps Research, La Jolla, California 92037, United States.

Meghan A Baker (MA)

Department of Chemistry, Scripps Research, La Jolla, California 92037, United States.

Masaki Ohtawa (M)

Department of Chemistry, Scripps Research, La Jolla, California 92037, United States.
ORCID: 0000-0001-7129-012X

Shuming Chen (S)

Department of Chemistry and Biochemistry, University of California at Los Angeles, Los Angeles, California 90095, United States.
ORCID: 0000-0003-1897-2249

Ching Ching Lam (CC)

Department of Chemistry and Biochemistry, University of California at Los Angeles, Los Angeles, California 90095, United States.

Sophia Khom (S)

Departments of Molecular Medicine and Neuroscience, Scripps Research, La Jolla, California 92037, United States.
ORCID: 0000-0003-3567-8973

Marisa Roberto (M)

Departments of Molecular Medicine and Neuroscience, Scripps Research, La Jolla, California 92037, United States.

Stefano Forli (S)

DISCoBio, Scripps Research, La Jolla, California 92037, United States.
ORCID: 0000-0002-5964-7111

Kendall N Houk (KN)

Department of Chemistry and Biochemistry, University of California at Los Angeles, Los Angeles, California 90095, United States.
ORCID: 0000-0002-8387-5261

Ryan A Shenvi (RA)

Department of Chemistry, Scripps Research, La Jolla, California 92037, United States.
ORCID: 0000-0001-8353-6449

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Classifications MeSH

questionsmedicales.fr › Produits chimiques inorganiques › Électrolytes › Ions › Anions › Bromures › Synthetic, Mechanistic, and Biological Interrogation of
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures cycliques › Hydrocarbures alicycliques › Cyclopentanes › Synthetic, Mechanistic, and Biological Interrogation of
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Furanes › Synthetic, Mechanistic, and Biological Interrogation of
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Agents neuromédiateurs › Agents GABA › Antagonistes GABA › Antagonistes du récepteur GABA-A › Synthetic, Mechanistic, and Biological Interrogation of
questionsmedicales.fr › Eucaryotes › Viridiplantae › Streptophyta › Embryophyta › Tracheobionta › Ginkgo biloba › Synthetic, Mechanistic, and Biological Interrogation of
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Terpènes › Diterpènes › Ginkgolides › Synthetic, Mechanistic, and Biological Interrogation of
questionsmedicales.fr › Techniques d'investigation › Marquage isotopique › Synthetic, Mechanistic, and Biological Interrogation of
questionsmedicales.fr › Composés chimiques organiques › Lactones › Synthetic, Mechanistic, and Biological Interrogation of
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Conformation moléculaire › Synthetic, Mechanistic, and Biological Interrogation of
questionsmedicales.fr › Métabolisme › Métabolisme énergétique › Oxydoréduction › Synthetic, Mechanistic, and Biological Interrogation of
questionsmedicales.fr › Phénomènes chimiques › Phénomènes de chimie organique › Isomérie › Stéréoisomérie › Synthetic, Mechanistic, and Biological Interrogation of