Membrane Interaction of Ibuprofen with Cholesterol-Containing Lipid Membranes.
NMR
cholesterol
fluorescence
ibuprofen
membrane interaction
membrane properties
Journal
Biomolecules
ISSN: 2218-273X
Titre abrégé: Biomolecules
Pays: Switzerland
ID NLM: 101596414
Informations de publication
Date de publication:
28 09 2020
28 09 2020
Historique:
received:
11
08
2020
revised:
25
09
2020
accepted:
26
09
2020
entrez:
1
10
2020
pubmed:
2
10
2020
medline:
2
9
2021
Statut:
epublish
Résumé
Deciphering the membrane interaction of drug molecules is important for improving drug delivery, cellular uptake, and the understanding of side effects of a given drug molecule. For the anti-inflammatory drug ibuprofen, several studies reported contradictory results regarding the impact of ibuprofen on cholesterol-containing lipid membranes. Here, we investigated membrane localization and orientation as well as the influence of ibuprofen on membrane properties in POPC/cholesterol bilayers using solid-state NMR spectroscopy and other biophysical assays. The presence of ibuprofen disturbs the molecular order of phospholipids as shown by alterations of the
Identifiants
pubmed: 32998467
pii: biom10101384
doi: 10.3390/biom10101384
pmc: PMC7650631
pii:
doi:
Substances chimiques
Lipid Bilayers
0
Phosphatidylcholines
0
Unilamellar Liposomes
0
Cholesterol
97C5T2UQ7J
1-palmitoyl-2-oleoylphosphatidylcholine
TE895536Y5
Ibuprofen
WK2XYI10QM
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Deutsche Forschungsgemeinschaft
ID : SCHE 1755/4-1
Pays : International
Organisme : Deutsche Forschungsgemeinschaft
ID : MU 1017/12-1
Pays : International
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