Identification of Compounds That Promote Readthrough of Premature Termination Codons in the CFTR.
Codon, Nonsense
Cystic Fibrosis
/ drug therapy
Cystic Fibrosis Transmembrane Conductance Regulator
/ genetics
Drug Discovery
/ methods
Drug Evaluation, Preclinical
/ methods
Gene Expression
Gene Expression Regulation
/ drug effects
Genes, Reporter
HEK293 Cells
High-Throughput Screening Assays
/ methods
Humans
Plasmids
/ genetics
Protein Biosynthesis
/ drug effects
Small Molecule Libraries
Transfection
/ methods
FMP
HTS
cell based
cystic fibrosis
ion channel
Journal
SLAS discovery : advancing life sciences R & D
ISSN: 2472-5560
Titre abrégé: SLAS Discov
Pays: United States
ID NLM: 101697563
Informations de publication
Date de publication:
Feb 2021
Feb 2021
Historique:
pubmed:
6
10
2020
medline:
19
2
2022
entrez:
5
10
2020
Statut:
ppublish
Résumé
Cystic fibrosis (CF) is caused by a mutation of the Cystic Fibrosis Transmembrane Conductance Regulator (
Identifiants
pubmed: 33016182
doi: 10.1177/2472555220962001
pmc: PMC7838340
pii: S2472-5552(22)06672-2
doi:
Substances chimiques
CFTR protein, human
0
Codon, Nonsense
0
Small Molecule Libraries
0
Cystic Fibrosis Transmembrane Conductance Regulator
126880-72-6
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
205-215Subventions
Organisme : NIH HHS
ID : S10 OD025279
Pays : United States
Organisme : NIH HHS
ID : S10 OD025282
Pays : United States
Organisme : NIH HHS
ID : S10 OD026857
Pays : United States
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